Results 111 to 120 of about 6,718,160 (281)

Tumor‐Intrinsic HEXB Drives Endothelial‐To‐Mesenchymal Transition and Confers Resistance to Anti‐Angiogenic Therapy in Glioblastoma

Advanced Science, EarlyView.
This study elucidates how glioblastoma tumors develop resistance to anti‐VEGF therapy through endothelial‐to‐mesenchymal transition (Endo‐MT). The researchers identify a novel signaling pathway where tumor‐derived HEXB stabilizes HSP60 to drive this vascular reprogramming.
Tianqi Liu, Xin Chen, Tao Sun, Jianqi Wu, Haixu Yan, Xing Liu, Hongda Lin, Xiangyu Wang, Ziao Xiao, Yang Xu, Qiang Fu, Peng Cheng, Wen Cheng, Anhua Wu   +13 more
wiley   +1 more source

Habitat‐Specific Design Strategies for Untethered Soft Robots

Advanced Science, EarlyView.
Habitat shapes the design of untethered soft robots. Across land, water, air, and living tissues, environmental constraints govern viable combinations of compliant structures, actuation mechanisms, and energy delivery. This review connects these constraints with robotic performance and identifies design principles for advancing adaptable, durable, and ...
Siyang Li, Zhikun Miao, Tuck‐Whye Wong, Tiefeng Li   +3 more
wiley   +1 more source

Mild neurological symptoms despite middle cerebral artery occlusion.

, 2004
BACKGROUND AND PURPOSE: Only a small percentage of stroke patients are treated with thrombolytic therapy. We sought to determine whether vessel occlusion in mild strokes represented a new target population for interventional therapy.
Coutts, SB, Hudon, ME, Hill, MD, Pexman, JH, Barber, PA, Buchan, Alastair, Demchuk, AM   +6 more
core   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Collateral Circulation and Outcome in Atherosclerotic Versus Cardioembolic Cerebral Large Vessel Occlusion

, 2019
Background and Purpose-Due to chronic hypoperfusion, cervical atherosclerosis may promote cerebral collateral circulation. We hypothesized that patients with ischemic stroke due to cervical carotid atherosclerosis have a more extensive collateral ...
Roos, Yvo B. W. E. M., Goldhoorn, Robert-Jan B., de Kort, Paul L. M., Dallinga, Rene J., Guglielmi, Valeria, van Hasselt, Boudewijn A. A. M., Wermer, Marieke J. H., van Oostenbrugge, Robert J., Zinkstok, Sanne M., Emmer, Bart J., Tolhuisen, Manon, Nijeholt, Geert J. Lycklama A., Aerden, Leo A. M., van Dijk, Ewoud J., Roozenbeek, Bob, Martens, Jasper M., van der Lugt, Aad, Roosendaal, Stefan D., Compagne, Kars C. J., Alves, Heitor, Eker, Reyhan, Postma, Alida A.; id_orcid, Keizer, Koos, Vos, Jan A., Schreuder, Tobien H. C. M. L., van Zwam, Wim H., Heijboer, Roel J. J., LeCouffe, Natalie E., Treurniet, Kilian M., Hofmeijer, Jeannette, Boers, Anna M. M., Majoie, Charles B. L. M., Postma, Alida A., van der Worp, H. Bart, Dippel, Diederik W. J., Berkhemer, Olvert A., Coutinho, Jonathan M., Marquering, Henk A., Staals, Julie, Groot, P. F. C., Boiten, Jelis, Uyttenboogaart, Maarten, van den Berg, René, van den Berg, Jan S. P., Schonewille, Wouter J., Lycklama À Nijeholt, Geert J., van Dijk, Lukas C., Boogaarts, Hieronymus D., van Kranendonk, Katinka R., Peluso, Jo P., Jansen, Ivo G. H., Sprengers, Marieke E. S., van Walderveen, Marianne A. A., Lo, Rob H., de Bruijn, Sebastiaan F., Hinsenveld, Wouter, Eshghi, Omid, Tolhuisen, Manon L., Kappelhof, Manon, Mulder, Maxim J. H. L., Beenen, Ludo F. M.   +60 more
core   +1 more source

AKAP1 Protects Retinal Ganglion Cells and Preserves Vision by Improving Mitochondrial and Synaptic Health in Glaucomatous Neurodegeneration

Advanced Science, EarlyView.
Intravitreal AAV2‐mediated AKAP1 restoration enhances mitochondrial fusion and biogenesis, improves bioenergetic capacity, and preserves mitochondrial integrity in glaucomatous RGCs. AKAP1 stabilizes presynaptic structure, maintaining synaptic protein expression, and limiting complement‐associated neuroinflammation.
Tonking Bastola, Keun‐Young Kim, Ziyao Shen, Guy A. Perkins, Muna Poudel, Yoonjin Lim, Hyejeong Choi, Soo‐Ho Choi, Mark H. Ellisman, Robert N. Weinreb, Won‐Kyu Ju   +10 more
wiley   +1 more source

Multiple small-vessel occlusions in systemic lupus erythematosus. [PDF]

Stroke, 1989
R A Asherson, E Baguley, M A Khamashta, G R Hughes   +3 more
openaire   +1 more source

Community Stroke Practice Experience with Small Vessel Thrombectomy

, 2019
Emergent endovascular revascularization is currently mainstay for patients presenting with emergent Large Vessel Occlusion (LVO) of the intracranial circulation Stroke symptoms affecting smaller vessels can carry significant morbidity Newer technologies ...
Carr, Kevin, MD, Pasquale, David, MD, Serulle, Yafell, MD, Thwing, Zachary, MD, Shivashankar, Ravishankar, MD   +4 more
core  

Branch vessel occlusion in aneurysm treatment with flow diverter stent

, 2020
: Flow diverter placement for treatment of intracranial aneurysms gained growing consensus in the past years. A major concern among professionals is the side branch coverage which leads in some cases to vessel occlusion.
Paolucci, Aldo, Carrafiello, Gianpaolo, Caranci, Ferdinando, Conte, Giorgio, Angileri, Alessio, Levi, Daniel, Hohenstatt, Sophia, Craparo, Giuseppe, Arrichiello, Antonio   +8 more
core   +1 more source

Astrocytic Ketogenesis Protects Central Nervous System Injury via CPT1A Stabilization and Epigenetic Regulation

Advanced Science, EarlyView.
A distinct astrocyte subpopulation, enriched at the lesion border, drives CNS repair through enhanced ketone body metabolism. This process promotes neuronal survival and axonal sparing via CPT1A stabilization and H3K9bhb‐dependent epigenetic reprogramming, positioning astrocytic ketogenesis as a promising therapeutic target for tissue regeneration ...
Dishui Pan, Haoming Shu, Rui Gao, Yilong Ren, Wu Ye, Xuhui Ge, Yao Gu, Yufeng Zhu, Xiaokun Wang, Honglin Teng, Xuhui Zhou, Wei Liu, Yang Gao, Jianquan Zhao, Weihua Cai   +14 more
wiley   +1 more source