Results 171 to 180 of about 11,122,863 (290)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Completion Small Bowel Capsule Endoscopy after Device-assisted Enteroscopy in Management of Patients with Small Bowel Disease. [PDF]

Endosc Int Open
Sihag S, Leung E, Costigan C, McNamara D.   +3 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

On-line Training for Small Business: Creating a Model of Best Practice

, 2006
Education and training can enhance small business owner/managers' managerial skills and is known to be effective in reducing small business failure. Training plays an important role in the competitive success of firms as people who acquire appropriate ...
Barrett, R, Stoney, S, Walker, EA, Webster, BJ   +3 more
core  

Appendiceal band syndrome causing acute small bowel obstruction with concomitant appendicitis: a case report. [PDF]

J Surg Case Rep
Hassan AI, Hassan HA, Elmi AM, Omar AA, Bashir AM, Nur NM.   +5 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Small business competition policy : are markets open for entrepreneurs? /

, 2008
"Small Business Committee Document Number 110-115."Shipping list no.: 2009-0111-P."One Hundred Tenth Congress, second session, hearing held September 25, 2008."Includes bibliographical references.Mode of access ...
United States. Congress. House. Committee on Small Business.
core  

DN4 Is Not a Screening Tool for Small Fiber Neuropathy: An Expected Result. [PDF]

Eur J Neurol
Lefaucheur JP.
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

The natural history of a successful, young, small, high technology company

, 1999
This paper reports the natural history of a successful, young, small, high-technology company in Perth, Western Australia. This case study is part of an ongoing larger survey concerning the success factors for Small and Medium Enterprises (SMEs) in this ...
Warren, L., Hutchinson, William E., Hutchinson, W.E., Warren, Lorraine   +3 more
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