Results 191 to 200 of about 7,463,915 (245)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Saliva vs Plasma in Liquid Biopsy Sampling for Head and Neck Cancer: A Comparative Study. [PDF]

Clin Chem
Barbirou M, Miller A, Baek D, Hameier A, Wetzel A, Fiedor J, Yang C, Linnenbach A, Nunes K, Llerena P, Samarah H, Bar-Ad V, Luginbuhl A, Li B, Li G, Yampolsky A, Hou L, Curry J, Wang C, Yang H.   +19 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Multiple breast tumors coexisting with chronic lymphocytic leukemia/small lymphocytic lymphoma: a rare case report. [PDF]

J Surg Case Rep
Allinjawi O, Sait S, Khan S, Fuadah S, Ajabnoor R, Shakra RA, Trabulsi N.   +6 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Six Cases of Borealpox and Evidence of a Zoonotic Source: Alaska, 2020-2023. [PDF]

Clin Infect Dis
Mooring EQ, Rogers J, Whitehill F, Werle Z, Gigante CM, Matheny A, Conley C, Westley BP, Kunkel A, Newell KG, Minhaj FS, Li Y, Morgan CN, Wilkins K, Davidson W, Nakazawa Y, McCollum AM, Olson V, Petersen BW, Castrodale LJ, Olson LE, Gunderson AM, Doty JB, McLaughlin JB.   +23 more
europepmc   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Violation detection in power operation sites based on multi-scale detection and few-shot learning. [PDF]

Front Artif Intell
Wen Y, Wang J, Liu Q, Zhou M, Tian M.
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Prognostic Models for Small Hepatocellular Carcinoma Using Inflammatory Indices and Machine Learning: A Propensity Score-Matched Study. [PDF]

Int J Gen Med
Cong Y, Gou Y, Ma Z, Huang W, Zhang L, Guo Q, Aji T, Shao Y.   +7 more
europepmc   +1 more source