Results 201 to 210 of about 7,463,915 (245)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Impulse Oscillometry Reveals Predominantly Mechanical Drivers of Small Airway Dysfunction in Obese Children. [PDF]

J Clin Med
Yılmaz E, Yamancan Yılmaz Z, Dündar İ, Çamtosun E, Topal E.   +4 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Accelerating Subcutaneous Drug Development: A Mechanistic Absorption Model for the Open Systems Pharmacology Framework. [PDF]

CPT Pharmacometrics Syst Pharmacol
Pellowe M, Dubbelboer I, Sjögren E.
europepmc   +1 more source

Mistaken Identity: Superior Mesenteric Vein Syndrome Presenting as Superior Mesenteric Artery Syndrome. [PDF]

ACG Case Rep J
Patel P, Vinall A, Patel S, Kuwelker S, Katabathina V, Echavarria J.   +5 more
europepmc   +1 more source

Transition-Transversion Bias at the <i>CYTB</i> Gene Level in the Order Cypriniformes (Actinopterygii) as Evidence for the Influence of Metabolic Rate on Molecular Evolutionary Rate. [PDF]

Ecol Evol
Mezhzherin SV, Morozov-Leonov SY.
europepmc   +1 more source

Recovery and Return to Sport in Pediatric Osteochondral Defects of the Knee: Evaluating the Influence of Lesion Size. [PDF]

Orthop J Sports Med
Corcoran E, Samuel Z, Force A, Gjonbalaj E, Mehraban Alvandi L, Fornari E, Drummond M.   +6 more
europepmc   +1 more source

Gallstone ileus due to a visible cholecystoduodenal fistula with pneumobilia CT diagnosis and surgical management: A case report. [PDF]

Radiol Case Rep
Ou-Skou L, Edderai M, Zamani O, Toufga Z, Abdellaoui M, Menaoui OE, En-Nouali H, Fenni JE, Saouab R, Boui M.   +9 more
europepmc   +1 more source

Autistic Traits in the UK Biobank

Fysh M, Matlock K, Tsompanidis A, Allison C, Weir E, Radecki M, Matthews F, Warrier V, Greenberg D, Braschi S, Baron-Cohen S.   +10 more
europepmc   +1 more source

Fractional exhaled nitric oxide at multiple flow rates in chronic cough: association with lung function and airway hyperresponsiveness. [PDF]

Ann Med
Wang D, Zhang Y, Liu Y.
europepmc   +1 more source