Results 81 to 90 of about 1,984,822 (289)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Small area estimation for semicontinuous data

Biometrical Journal, 2014
Survey data often contain measurements for variables that are semicontinuous in nature, i.e. they either take a single fixed value (we assume this is zero) or they have a continuous, often skewed, distribution on the positive real line. Standard methods for small area estimation (SAE) based on the use of linear mixed models can be inefficient for such ...
Chandra, Hukum, Chambers, Raymond L
openaire   +5 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Analyzing regional patterns of mortality data quality and adult mortality for small areas in Brazil, 1980–2010 [PDF]

Demographic Research
BACKGROUND: Brazil’s profound regional social inequalities raise concerns about their impact on adult mortality and data quality. Although the quality of mortality data has improved in recent decades, substantial regional disparities in death ...
Everton Lima, Bernardo Lanza Queiroz, Flavio Freire, Marcos Gonzaga   +3 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Out of Sample Estimation for Small Areas using Area Level Data

, 2005
A Fay-Herriot type model with independent area effects is often assumed when small area estimates based on area level data are required. However, under this approach out of sample areas are limited to synthetic estimates.
Chambers, Ray, Saei, Ayoub
core  

Small Area Estimates for Cross-Classifications

Journal of the Royal Statistical Society Series B: Statistical Methodology, 2004
SummaryWe develop a class of log-linear structural models that is suited to estimation of small area cross-classified counts based on survey data. This allows us to account for various associ- ation structures within the data and includes as a special case the restricted log-linear model underlying structure preserving estimation.
Zhang, Li-Chun, Chambers, Raymond L.
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Small-area estimation with spatial similarity [PDF]

A class of composite estimators of small area quantities that exploit spatial (distancerelated) similarity is derived. It is based on a distribution-free model for the areas, but the estimators are aimed to have optimal design-based properties ...
Nicholas Longford
core  

Dominance properties of constrained Bayes and empirical Bayes estimators

, 2013
This paper studies decision theoretic properties of benchmarked estimators which are of some importance in small area estimation problems. Benchmarking is intended to improve certain aggregate properties (such as study-wide averages) when model based ...
Kubokawa, Tatsuya, Strawderman, William E.   +1 more
core   +1 more source