Results 81 to 90 of about 1,760,812 (299)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Small Area Estimation under Poisson–Dirichlet Process Mixture Models

Axioms
In this paper, we propose an improved Nested Error Regression model in which the random effects for each area are given a prior distribution using the Poisson–Dirichlet Process. Based on this model, we mainly investigate the construction of the parameter
Xiang Qiu, Qinchun Ke, Xueqin Zhou, Yulu Liu   +3 more
doaj   +1 more source

Analysis of area level and unit level models for small area estimation in forest inventories assisted with LiDAR auxiliary information

PLoS ONE, 2017
Forest inventories require estimates and measures of uncertainty for subpopulations such as management units. These units often times hold a small sample size, so they should be regarded as small areas.
F. Mauro, V. Monleon, H. Temesgen, Kevin R. Ford   +3 more
semanticscholar   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Simulation Tools for Small Area Estimation: Introducing the R-package saeSim

Austrian Journal of Statistics, 2016
The demand for reliable regional estimates from sample surveys has been substantially grown over the last decades. Small area estimation provides statistical methods to produce reliable predictions when the sample sizes in regions are too small to apply ...
Sebastian Warnholz, Timo Schmid
doaj   +1 more source

Small Area Estimates for Cross-Classifications

Journal of the Royal Statistical Society Series B: Statistical Methodology, 2004
SummaryWe develop a class of log-linear structural models that is suited to estimation of small area cross-classified counts based on survey data. This allows us to account for various associ- ation structures within the data and includes as a special case the restricted log-linear model underlying structure preserving estimation.
Zhang, Li-Chun, Chambers, Raymond L.
openaire   +2 more sources

A Double-Sampling Extension of the German National Forest Inventory for Design-Based Small Area Estimation on Forest District Levels

Remote Sensing, 2018
The German National Forest Inventory consists of a systematic grid of permanent sample plots and provides a reliable evidence-based assessment of the state and the development of Germany’s forests on national and federal state level in a 10 year interval.
Andreas Hill, D. Mandallaz, Joachim Langshausen   +2 more
semanticscholar   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Estimating uncertainty in spatial microsimulation approaches to small area estimation: A new approach to solving an old problem

Computers, Environment and Urban Systems, 2017
A wide range of user groups from policy makers to media commentators demand ever more spatially detailed information yet the desired data are often not available at fine spatial scales. Increasingly, small area estimation (SAE) techniques are called upon
A. Whitworth, E. Carter, D. Ballas, G. Moon   +3 more
semanticscholar   +1 more source