Results 51 to 60 of about 5,765,825 (296)

A woman with anemia and a small-bowel obstruction [PDF]

open access: yesCanadian Medical Association Journal, 2004
A previously well 60-year-old woman presented to hospital with a 3-week history of fatigue, anorexia, abdominal pain, nausea and vomiting, and a 4-kg weight loss. She had previously consulted her general practitioner about an episode of diarrhea and dark stools and was found at that time to ...
PIRISI, Mario   +3 more
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

An Unusual Cause of Small Bowel Obstruction in a Child: Ingested Rhubarb

open access: yesCase Reports in Surgery, 2013
Small bowel obstruction is rarely caused by bezoars concretions formed from undigested foreign material in the gastrointestinal tract. An important cause of bezoars is phytobezoars, formed from vegetables or fruits.
Miguel Glatstein   +4 more
doaj   +1 more source

An Uncommon Cause of a Small-Bowel Obstruction [PDF]

open access: yesCase Reports in Gastrointestinal Medicine, 2017
Sarcoidosis is a systemic granulomatous disease of unknown etiology, characterized by the formation of noncaseating granulomas. Gastrointestinal (GI) system involvement that is clinically recognizable occurs in less than 0.9% of patients with sarcoidosis, with data revealing small intestine involvement in 0.03% of the cases.
Ali Zakaria   +4 more
openaire   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

A review of the radiological imaging modalities of non-traumatic small bowel obstruction

open access: yesSouth African Family Practice, 2015
Small bowel obstruction is a common clinical presentation that presents a diagnostic conundrum. Over the last 2 decades, there has been a paradigm shift in the radiological investigation of small bowel obstruction (SBO) and in the indication for and ...
Narisha Maharaj, Bhugwan Singh
doaj   +1 more source

Small bowel volvulus (SBV) in Northcentral Ethiopia

open access: yesBMC Surgery, 2020
Background Small bowel volvulus (SBV) is a benign gastrointestinal surgical condition in which there is a torsion of all or parts of a segment of small bowel on its mesenteric axis.
Atalel Fentahun Awedew   +3 more
doaj   +1 more source

Spectrum of MDCT Findings in Bowel Obstruction in a Tertiary Care Rural Hospital in Northern India [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2016
Introduction: Multidetector Computed Tomography (MDCT) provides clinically and surgically important information in bowel obstruction. It can depict the severity, level and cause of obstruction. Aim: To depict the spectrum of MDCT findings in cases of
Ranjana Gupta   +5 more
doaj   +1 more source

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