Results 271 to 280 of about 3,082,206 (396)

Predicting Macrophage Spatial Localization from Single‐Cell Transcriptomes to Uncover Disease Mechanisms

Advanced Science, EarlyView.
This study presents a machine‐learning framework entitled MERLIN that infers the microanatomical localization of macrophages from single‐cell transcriptomic data in structured organs such as the kidney and brain. Applying this method to existing datasets from models of acute kidney injury and diabetic nephropathy uncovered spatially resolved insights ...
Junping Yin, Qi Mei, Hans‐Joachim Paust, Ning Song, Yu Zhao, Daniela Klaus, Melanie Eichler, Yijun Hua, Jie Qin, Weiting Cheng, Christina K. Weisheit, Veronika Lukacs‐Kornek, Isis Ludwig‐Portugall, Sibylle von Vietinghoff, Christian F. Krebs, Johanna Klughammer, Ulf Panzer, Christian Kurts, Jian Li   +18 more
wiley   +1 more source

TOP2A as a prognostic biomarker in small cell carcinoma of the esophagus: an integrated bioinformatics and immunohistochemical study. [PDF]

Front Mol Biosci
Yin X, Li X, Mi L, Hou J, Yin F.
europepmc   +1 more source

Classification of Non-small Cell Lung Carcinoma in Transthoracic Needle Specimens Using MicroRNA Expression Profiling

, 2011
Ambrogio Fassina, Rocco Cappellesso, Matteo Fassan   +2 more
openalex   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Case Report: Hypercalcemic small-cell carcinoma of the ovary during pregnancy: diagnostic and therapeutic challenges. [PDF]

Front Oncol
Tripepi M, da Costa AG, Albergaria D, Costa A, Catarino A, Duarte AL, Bartosch C, Schuler V, Oliveira J, Lima J, Casanova J.   +10 more
europepmc   +1 more source

Kanglaite injection combined with chemotherapy versus chemotherapy alone in the treatment of advanced non-small cell lung carcinoma

, 2014
Xiaoge Kou, Xiaohong Liu, Yang Qinghui, Yuling Xi, Kewei Yu, Weizhen Wang, Xiangmei Zhao   +6 more
openalex   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Lambert-Eaton myasthenic syndrome presenting with occult mediastinal small cell carcinoma and positivity for anti-CV2/CRMP5 and anti-SOX1 antibodies: a case report. [PDF]

BMC Neurol
Wang A, Li H, Li D, Wang K, Zhang L.
europepmc   +1 more source

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
Fibroblast activation protein alpha‐positive (FAPα+) macrophages, a distinct subset of multiple myeloma (MM)‐associated macrophages, drive immune evasion in MM through multi‐faceted mechanisms. FAPα physically interacts with vimentin (VIM) and triggers its phosphorylation at the S72 residue, which in turn induces PD‐L1 transcription. Additionally, FAPα
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

Extrapulmonary small cell carcinoma of the liver treated with chemotherapy and durvalumab. [PDF]

Radiol Case Rep
Golemba AS, Santamaría AAA, Tolosa REG.
europepmc   +1 more source