Results 101 to 110 of about 4,120,866 (281)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Small deviations in $L_2$-norm for Gaussian dependent sequences

Electronic Communications in Probability, 2016
Let $U=(U_k)_{k\in\mathbb{Z}}$ be a centered Gaussian stationary sequence satisfying some minor regularity condition. We study the asymptotic behavior of its weighted $\ell_2$-norm small deviation probabilities. It is shown that \[ \ln \mathbb{P}\left( \sum_{k\in\mathbb{Z}} d_k^2 U_k^2 \leq \varepsilon^2\right) \sim - M \varepsilon^{-\frac{2}{2p-1 ...
Hong, Seok Young, Lifshits, Mikhail, Nazarov, Alexander   +2 more
openaire   +4 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Comparative analysis of earthquake parameter measurement results and earthquake data of Shanxi early warning station

地震科学进展
In this paper, the actual earthquake cases of Shanxi seismic network from September 2021 to March 2023 are selected. Based on the official cataloging results of China Earthquake Network, the earthquake onset time, epicenter location and magnitude ...
Xuejiao Liu, Rui Lü, Kaiyu Feng, Liting Dou, Qianchong Chen   +4 more
doaj   +1 more source

Dynamical Properties of the Fisher–Kolmogorov–Petrovskii–Piscounov Equation with Deviation of the Spatial Variable

Моделирование и анализ информационных систем, 2015
We consider the problem of density wave propagation of a logistic equation with deviation of the spatial variable and diffusion (Fisher-Kolmogorov equation with deviation of the spatial variable).
S. V. Aleshin, S. D. Glyzin, S. A. Kaschenko   +2 more
doaj   +1 more source

Large and Small Deviations for Statistical Sequence Matching

IEEE Transactions on Information Theory
We revisit the problem of statistical sequence matching between two databases of sequences initiated by Unnikrishnan (TIT 2015) and derive theoretical performance guarantees for the generalized likelihood ratio test (GLRT). We first consider the case where the number of matched pairs of sequences between the databases is known.
Lin Zhou, Qianyun Wang, Jingjing Wang, Lin Bai, Alfred O. Hero   +4 more
openaire   +3 more sources