Results 71 to 80 of about 296,266 (336)

Subventricular Zone‐on‐a‐Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage

Advanced Science, EarlyView.
A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Laura Nicoleti Zamproni, Begüm Gökçe, Magnus Gram, Coco Holliday, Aylin Sendemir, Marimélia Aparecida Porcionatto, Anna Herland   +6 more
wiley   +1 more source

Use of a Feed-Forward Back Propagation Network for the Prediction of Small for Gestational Age Newborns in a Cohort of Pregnant Patients with Thrombophilia

Diagnostics, 2022
(1) Background: Fetal growth restriction is a relatively common disorder in pregnant patients with thrombophilia. New artificial intelligence algorithms are a promising option for the prediction of adverse obstetrical outcomes.
Petronela Vicoveanu, Ingrid Andrada Vasilache, Ioana Sadiye Scripcariu, Dragos Nemescu, Alexandru Carauleanu, Dragos Vicoveanu, Ana Roxana Covali, Catalina Filip, Demetra Socolov   +8 more
doaj   +1 more source

Birth outcomes for African and Caribbean babies in England and Wales: retrospective analysis of routinely collected data [PDF]

, 2012
Objectives: To compare mean birth weights, gestational ages and odds of preterm birth and low birth weight of live singleton babies of black African or Caribbean ethnicity born in 2005 or 2006 by mother's country of birth.
Datta-Nemdharry, P., Dattani, N., Macfarlane, A. J.   +2 more
core   +2 more sources

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Perinatal factors impacting echocardiographic left ventricular measurement in small for gestational age infants: a prospective cohort study

BMC Pediatrics, 2023
Introduction Infants born small for gestational age (SGA) have an increased risk of developing various cardiovascular complications. While many influencing factors can be adjusted or adapt over time, congenital factors also have a significant role.
Ibrahim Elmakaty, Ahmed Amarah, Michael Henry, Manoj Chhabra, Danthanh Hoang, Debbie Suk, Nitin Ron, Beata Dygulska, Farrah Sy, Madhu B. Gudavalli, Ali M. Nadroo, Pramod Narula, Ashraf Gad   +12 more
doaj   +1 more source

Promotion of faster weight gain in infants born small for gestational age - Is there an adverse effect on later blood pressure? [PDF]

, 2007
Background - Being born small for gestational age is associated with later risk factors for cardiovascular disease, such as high blood pressure. Promotion of postnatal growth has been proposed to ameliorate these effects. There is evidence in animals and
Alan Lucas, Alan Lucas, Atul Singhal, Fmed Sci, Kathy Kennedy, Mary Fewtrell, Terence Stephenson, Tim J. Cole   +7 more
core  

Estimation of causal effects using instrumental variables with nonignorable missing covariates: Application to effect of type of delivery NICU on premature infants [PDF]

, 2014
Understanding how effective high-level NICUs (neonatal intensive care units that have the capacity for sustained mechanical assisted ventilation and high volume) are compared to low-level NICUs is important and valuable for both individual mothers and ...
Lorch, Scott A., Small, Dylan S., Yang, Fan   +2 more
core   +3 more sources

Bisphenol B Exposure Induces Miscarriage by Suppressing Migration/Invasion and Migrasome Formation

Advanced Science, EarlyView.
BPB (Bisphenol B) exposure up‐regulates ER (estrogen receptor) levels, enhances its interactions with the lnc‐HZ04 promoter region, and thus promotes ER‐mediated lnc‐HZ04 transcription. Subsequently, lnc‐HZ04 suppresses TCF4 (transcription factor 4)‐mediated PKCA (protein kinase C alpha) transcription and subsequently suppresses migration/invasion and ...
Wenxin Huang, Manli Wang, Yi Sun, Xiaoping Yue, Xun Li, Yanbing Lin, Geng Guo, Depeng Zhao, Qigang Fan, Xiaoling Ma, Zhihong Zhang, Shuaishuai Xing, Xiaoting Shen, Huidong Zhang   +13 more
wiley   +1 more source

Gestational age at delivery and special educational need: retrospective cohort study of 407,503 schoolchildren [PDF]

, 2010
<STRONG>Background</STRONG> Previous studies have demonstrated an association between preterm delivery and increased risk of special educational need (SEN).
A Brady, AL Rickards, AT Bhutta, BE Stephens, CM McCarton, D Wolke, Daniel F. MacKay, G Wiener, Gordon C. S. Smith, I Kirkegaard, J Briscoe, J Cuzick, Jill P. Pell, LA Foulder-Hughes, M Lagerstrom, M Ornstein, MG Eide, MJ Davidoff, P Royston, PJ Anderson, RG Record, Richard Dobbie, S Campbell, S Yang, SK Cole, Tze Kin Lau   +25 more
core   +4 more sources

Nanoscale Mapping of the Subcellular Glycosylation Landscape

Advanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski   +4 more
wiley   +1 more source