Results 81 to 90 of about 86,851,642 (308)

Endowing Flexibility of Alveolar Type II Cells to Recapitulate Development From Lung Bud to Alveoli

Advanced Science, EarlyView.
Adult human alveolar type 2 cells are chemically reprogrammed into expandable alveolar progenitor‐like cells that acquire bud tip‐like features during expansion and form organoids that mature into alveolar‐like structures. These organoids model influenza A virus infection and innate immune responses in vitro, while transplanted cells engraft ...
Hongqian Ma, Yuxin Zhang, Lujia Sun, Hong Jiang, Fan Li, Wenming Liu, Shenao Zhou, Mengting Wang, Weijian Huang, Xu Zhou, Caiyang Chen, Qiuqiu Zhang, Xiaoyan Jin, Feihan Yan, Hongping Wu, Yonghong Yin, Xinling Wang, Hexin Yan, Weifeng Yu   +18 more
wiley   +1 more source

Biochemical and metabolic profile in small for gestational age (SGA) and appropriate for gestational age (AGA) subjects at 9 years.

, 2020
Biochemical and metabolic profile in small for gestational age (SGA) and appropriate for gestational age (AGA) subjects at 9 years.
Lena Legnevall (8357313), Daniela Germani (48404), Mireille Vanpee (8357310), Annalisa Deodati (5391173), Anna Kistner (645022), Stefano Cianfarani (48406), Elena Inzaghi (8357307), Katarina Berinder (2152705)   +7 more
core   +1 more source

Table1_Cord blood fatty acid binding protein 4 and lipids in infants born small- or large-for-gestational-age.pdf

, 2023
AimAdverse (poor or excessive) fetal growth “programs” an elevated risk of type 2 diabetes. Fatty acid binding protein 4 (FABP4) has been implicated in regulating insulin sensitivity and lipid metabolism relevant to fetal growth.
Hua He (120374), Jun Zhang (48506), Fang Fang (38179), Rong Huang (298496), Tao Zheng (146941), Fei Li (143236), Guang-Hui Zhang (582109), Wen-Juan Wang (403476), Yu Dong (398252), Min-Yi Tao (12755054), Ya-Jie Xu (12755051), Jian-Gao Fan (2824859), Zhong-Cheng Luo (297783), Xin Liu (43569), Meng-Nan Yang (4430497), Fengxiu Ouyang (585572)   +15 more
core   +1 more source

Developmentally Guided Differentiation of Ventral Midbrain Dopaminergic Cells Validated in Proteopathy‐Based Parkinson's Disease Models

Advanced Science, EarlyView.
A developmentally guided protocol reproducibly specifies EN1‐positive ventral midbrain dopaminergic (vmDA) progenitors from human pluripotent stem cells and yields functional vmDA neurons. Optogenetic induction of α‐synuclein aggregation elicits selective degeneration of TH‐positive neurons in 2D cultures and 3D neurospheroids, while transplanted ...
Heechang Moon, Heejeong Kim, Elliot H. Lee, Hanseul Kim, Ji Hun Kim, Huisu Jeong, Jiwon Cheon, Ga Ram Jeong, Byoung Dae Lee, Jae‐Won Cho, Soo‐Jin Oh, Yunjong Lee, Yohan Oh   +12 more
wiley   +1 more source

Biochemical and metabolic profile between small for gestational age (SGA) and appropriate for gestational age (AGA) subjects at 21 years.

, 2020
Biochemical and metabolic profile between small for gestational age (SGA) and appropriate for gestational age (AGA) subjects at 21 years.
Lena Legnevall (8357313), Daniela Germani (48404), Mireille Vanpee (8357310), Annalisa Deodati (5391173), Anna Kistner (645022), Stefano Cianfarani (48406), Elena Inzaghi (8357307), Katarina Berinder (2152705)   +7 more
core   +1 more source

Etiological Subgroups of Small-for-Gestational-Age: Differential Neurodevelopmental Outcomes. [PDF]

, 2016
It remains unclear why substantial variations in neurodevelopmental outcomes exist within small-for-gestational-age (SGA) children. We prospectively compared 5-y neurodevelopmental outcomes across SGA etiological subgroups.Children born SGA (N = 1050 ...
Xiuhong Li, Rina D Eiden, Xiuhong Li (378121), Xiaozhong Wen (111666), Edmond D Shenassa, Chuanbo Xie, Leonard H. Epstein (2921427), Chuanbo Xie (564299), Xiaozhong Wen, Leonard H Epstein, Rina D. Eiden (2921430), Edmond D. Shenassa (65093)   +11 more
core   +1 more source

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

Advanced Science, EarlyView.
Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen, Bin He, Kuan Liu, Zhuo Ma, Bin Xu   +4 more
wiley   +1 more source

Small-for-gestational age prevalence risk factors in central Appalachian states with mountain-top mining [PDF]

, 2017
Objectives To identify risk factors for small-for-gestational age (SGA) for counties in central Appalachian states (Kentucky (KY), Tennessee (TN), Virginia (VA), and West Virginia (WV)) with varied coal mining activities. Material and Methods Live birth
Chen, Rusan, Manning Feinleib, Feinleib, Manning, Steve Lamm, Ferdosi, Hamid, Afari-Dwamena, Nana A., Hamid Ferdosi, Nana Ama Afari-Dwamena, Nana Afari-Dwamena, Dissen, Elisabeth, Elisabeth Dissen, Afari-Dwamena, Nana Ama, Lamm, Steve H, Lamm, Steve H., Steve H. Lamm, Rusan Chen, Li, Ji, Ji Li   +17 more
core   +2 more sources

Arhgef1 Deletion Disrupts Early Cortical Neurogenesis via PAK1 Overactivation and Causes Motor Dysfunction in Adulthood

Advanced Science, EarlyView.
ARHGEF1 plays a pivotal role in both embryonic cortical neurogenesis and adult motor function. During early development, it governs genesis of deep‐layer cortical neurons by negatively regulating RAC1/CDC42‐PAK1‐Cofilin signaling. In adulthood, ARHGEF1 is important for the maintenance of neuronal morphology and activity in the motor cortex, ensuring ...
Liuren Li, Xuanyue Ma, Zhenyu Ding, Bang Sun, Linglin Liu, Hei Matthew Yip, Wei Wang, Tianying Wu, Yuan Guo, Yinghui Peng, Shiqing Zhang, Jacque Pak Kan Ip, Li Zhang, Keshen Li, Lei Shi   +14 more
wiley   +1 more source

Predictive performance for placental dysfunction related stillbirth of the competing risks model for small‐for‐gestational‐age fetuses

, 2022
Objectives: To examine the predictive performance for placental dysfunction related stillbirths of the competing risks model for small-for-gestational-age (SGA) fetuses based on fetusa combination of maternal risk factors, estimated fetal weight
Papastefanou, I., Nicolaides, Kypros H., Akolekar, Ranjit, Ashoor, Ghalia, Syngelaki, Argyro   +4 more
core   +1 more source