Results 71 to 80 of about 193,103 (310)

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Change of maternal weight gain trajectory following lifestyle interventions for gestational diabetes and its impact on abnormal infant birthweight: an observational study based on longitudinal weight measurements

BMC Pregnancy and Childbirth
Background Restricted gestational weight gain (GWG) following lifestyle interventions for gestational diabetes mellitus (GDM) has been observed in clinical trials but not been explicitly confirmed in real-world clinical settings.
Juan Li, Chuanzi Yang, Kuanrong Li
doaj   +1 more source

Early pregnancy metabolic syndrome and risk for adverse pregnancy outcomes: findings from Rajarata Pregnancy Cohort (RaPCo) in Sri Lanka

BMC Pregnancy and Childbirth, 2023
Background Despite the intergenerational effects of metabolic disorders, evidence is greatly lacking on early pregnancy metabolic syndrome (MetS) and its effects on pregnancy outcomes from low- and middle-income countries.
Imasha Upulini Jayasinghe, Thilini Chanchala Agampodi, Ajith Kumara Dissanayake, Suneth Buddhika Agampodi   +3 more
doaj   +1 more source

Gestational age at delivery and special educational need: retrospective cohort study of 407,503 schoolchildren [PDF]

, 2010
<STRONG>Background</STRONG> Previous studies have demonstrated an association between preterm delivery and increased risk of special educational need (SEN).
Daniel F. MacKay, Gordon C. S. Smith, Dobbie, R., Gordon C S Smith, Dobbie Richard, Pell, J.P., MacKay Daniel F., Mackay, D.F., Jill P Pell, Daniel F MacKay, Smith, G.C.S., Smith Gordon C. S., Pell Jill P., Richard Dobbie, Jill P. Pell   +14 more
core   +1 more source

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery

Environmental Health, 2021
Background While fetal growth is a tightly regulated process, it is sensitive to environmental exposures that occur during pregnancy. Many commonly used consumer products contain chemicals that can disturb processes underlying fetal growth.
P. A. Bommarito, B. M. Welch, A. P. Keil, G. P. Baker, D. E. Cantonwine, T. F. McElrath, K. K. Ferguson   +6 more
doaj   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Screening for gestational diabetes : a systematic review and economic evaluation [PDF]

, 2002
Background Screening for gestational diabetes mellitus (GDM) has been controversial, with some expert bodies advising universal screening, others selective screening, and yet others advising against screening at all.
N. Waugh, D.A. Scott, McIntyre, L, Waugh, Norman, Loveman, E, Loveman, E., Scott, D A, Waugh, N, McIntyre, Linda, L. McIntyre, Scott, David A., E. Loveman   +11 more
core   +1 more source

Anthropometric and body composition data at child follow-up visits, as grouped by birth weight categorization into small-for-gestational age and appropriate-for-gestational age.

, 2021
Anthropometric and body composition data at child follow-up visits, as grouped by birth weight categorization into small-for-gestational age and appropriate-for-gestational age.
Helen Mulol (11250675), Valerie Vannevel (10138660), Robert Pattinson (233259), Ute Feucht (11250672)   +3 more
core   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source