Results 101 to 110 of about 10,910,180 (370)

Correction of small bowel function as a new direction for treating patients with metabolic syndrome [PDF]

open access: yesТерапевтический архив, 2017
Aim. To provide a rationale for and to evaluate the therapeutic efficiency of the combined use of pancreatic enzymes and actovegin in the combination therapy of patients with metabolic syndrome (MS) on the basis of comprehensive clinical and functional ...
Ya M Vakhrushev, M V Lyapina
doaj   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

open access: yesFEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze   +3 more
wiley   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

A counterexample to 'Algebraic function fields with small class number' [PDF]

open access: yes, 2013
I give a counter example of function field over GF(2) of genus 4 with class number one.
Stirpe, Claudio
core  

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Stability of a characterization of normal distributions based on the first two conditional moments

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2000
A characterization of normal distributions of two independent random variables X and Y with a finite E[X2] based on the linearity of E[X|X+Y] and the homoscedasticity of var[X|X+Y] given by Rao (1976) is proved to be stable.
Truc T. Nguyen, Khoan T. Dinh
doaj   +1 more source

Small values of the Euler function and the Riemann hypothesis

open access: yes, 2012
Let $\vfi$ be Euler's function, $\ga$ be Euler's constant and $N_k$ be the product of the first $k$ primes. In this article, we consider the function $c(n) =(n/\vfi(n)-e^\ga\log\log n)\sqrt{\log n}$. Under Riemann's hypothesis, it is proved that $c(N_k)$
Nicolas, Jean-Louis
core   +3 more sources

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Derivatives of Meromorphic Functions with Multiple Zeros and Small Functions

open access: yesAbstract and Applied Analysis, 2014
Letfzbe a meromorphic function inℂ, and letαz=Rzhz≢0, wherehzis a nonconstant elliptic function andRzis a rational function. Suppose that all zeros offzare multiple except finitely many andTr,α=oTr,fasr→∞. Thenf'z=αzhas infinitely many solutions.
Pai Yang, Peiyan Niu
openaire   +4 more sources

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