Results 281 to 290 of about 7,610,404 (354)

The Small GTPase RhoA Is Required for Proper Locomotor Circuit Assembly

, 2013
Shalaka Mulherkar, Feng Liu, Qin Chen, Anjana S. Narayanan, Anthony D. Couvillon, H. David Shine, Kimberley F. Tolias   +6 more
openalex   +2 more sources

Expression of Rem2, an RGK Family Small GTPase, Reduces N-Type Calcium Current without Affecting Channel Surface Density [PDF]

, 2005
Huanmian Chen, Henry L. Puhl, Shui‐Lin Niu, Drake C. Mitchell, Stephen R. Ikeda   +4 more
openalex   +1 more source

MHC Class II Presentation Is Controlled by the Lysosomal Small GTPase, Arl8b

Journal of Immunology, 2015
X. Michelet, S. Garg, B. Wolf, A. Tuli, P. Ricciardi-Castagnoli, M. Brenner   +5 more
semanticscholar   +1 more source

The C‐Terminal Regions of TRAK Proteins Contain MIRO‐Independent Mitochondrial Localization Domains

Cytoskeleton, EarlyView.
ABSTRACT Current models suggest that MIRO GTPases anchor cytoskeletal motors to the mitochondrial outer membrane (MOM). However, our previous findings indicate that the unconventional myosin, MYO19, interacts with MIRO weakly and that a MIRO‐independent MOM‐localizing domain interacts more tightly with the MOM.
Lili Mitchell, Kathryn E. Reda, Hijab Fatima, Claudia E. Vasquez, Omar A. Quintero‐Carmona   +4 more
wiley   +1 more source

Protocadherin-7 Regulates Monocyte Migration Through Regulation of Small GTPase RhoA and Rac1. [PDF]

Int J Mol Sci
Kim H, Takegahara N, Choi Y.
europepmc   +1 more source

Unraveling Novel Genetic Determinants of Thiopurine Response Via TWAS

Clinical Pharmacology &Therapeutics, EarlyView.
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Thiopurines such as 6‐mercaptopurine (6MP) are essential in ALL maintenance therapy. However, dose‐limiting toxicities can significantly disrupt treatment. While genetic variants in TPMT and NUDT15 are known to affect thiopurine response, many patients with normal function ...
Carlotta Bidoli, Wenjian Yang, Seth E. Karol, Marianna Lucafò, Gabriele Stocco, Jun J. Yang   +5 more
wiley   +1 more source

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, EarlyView.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

The Small GTPase Ran Increases Sensitivity of Ovarian Cancer Cells to Oncolytic Vesicular Stomatitis Virus. [PDF]

Pharmaceuticals (Basel)
Geoffroy K, Viens M, Kalin EM, Boudhraa Z, Roy DG, Wu JH, Provencher D, Mes-Masson AM, Bourgeois-Daigneault MC.   +8 more
europepmc   +1 more source

Altered Inflammatory Signature in a C9ORF72‐ALS iPSC‐Derived Motor Neuron and Microglia Coculture Model

Glia, EarlyView.
Established a C9ORF72 ALS microglia and motor neuron coculture model. Identified an altered inflammatory signature in C9ORF72 ALS microglia. Single‐cell RNA sequencing detected the removal of an LPS responsive microglia subpopulation. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder involving multiple cell types in ...
Yujing Gao, Jessica L. Brothwood, Harpreet Saini, Gregory A. O'Sullivan, Carla F. Bento, James M. McCarthy, Nicola G. Wallis, Elena Di Daniel, Brent Graham, Daniel M. Tams   +9 more
wiley   +1 more source

Extracellular vesicle formation in Euryarchaeota is driven by a small GTPase. [PDF]

Proc Natl Acad Sci U S A
Mills J, Gebhard LJ, Schubotz F, Shevchenko A, Speth DR, Liao Y, Duggin IG, Marchfelder A, Erdmann S.   +8 more
europepmc   +1 more source