Multi-color fluorescence live-cell imaging in Dictyostelium discoideum
Cell Structure and FunctionThe cellular slime mold Dictyostelium discoideum, a member of the Amoebozoa, has been extensively studied in cell and developmental biology. D. discoideum is unique in that they are genetically tractable, with a wealth of data accumulated over half a ...
Hidenori Hashimura +8 more
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Nucleophosmin1 is a negative regulator of the small GTPase Rac1. [PDF]
PLoS ONE, 2013 The Rac1 GTPase is a critical regulator of cytoskeletal dynamics and controls many biological processes, such as cell migration, cell-cell contacts, cellular growth and cell division.
Younes Zoughlami +3 more
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Disrupting the ciliary gradient of active Arl3 affects rod photoreceptor nuclear migration
eLife, 2023 The small GTPase Arl3 is important for the enrichment of lipidated proteins to primary cilia, including the outer segment of photoreceptors. Human mutations in the small GTPase Arl3 cause both autosomal recessive and dominant inherited retinal ...
Amanda M Travis +5 more
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Small GTPase patterning: How to stabilise cluster coexistence.
PLoS ONE, 2019 Many biological processes have to occur at specific locations on the cell membrane. These locations are often specified by the localised activity of small GTPase proteins.
Bas Jacobs, Jaap Molenaar, Eva E Deinum
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The small GTPase RhoB regulates TNFα signaling in endothelial cells. [PDF]
PLoS ONE, 2013 The inflammatory response of endothelial cells triggered by cytokines such as TNFα and IL1β plays a pivotal role in innate immunity. Upon pro-inflammatory cytokine stimulation, endothelial cells produce chemokines and cytokines that attract and activate ...
Jeffrey Kroon +4 more
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Frontiers in Marine Science, 2023 The Ras superfamily of small guanosine triphosphatases (GTPases) are a large group of small GTP-binding proteins, which play crucial roles in basic cellular processes in all eukaryotes. In this study, by analyzing the gene structure, temporal and spatial
Shuqing Si +18 more
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Novel role of Ras-GTPase Activating Protein SH3 Domain-Binding Protein G3BP in adhesion and migration of 32D myeloid progenitor cells [PDF]
, 2012 Rho GTPases are involved in homing and mobilization of hematopoietic stem and progenitor cells due to their impact on cytoskeleton remodeling. We have previously shown that inhibition of Rho, Rac and Cdc42 clearly impairs adhesion of normal and leukemic ...
Aschenbrenner, Frank +8 more
core +1 more source
Turing instabilities in a mathematical model for signaling networks
, 2011 GTPase molecules are important regulators in cells that continuously run through an activation/deactivation and membrane-attachment/membrane-detachment cycle. Activated GTPase is able to localize in parts of the membranes and to induce cell polarity.
AB Goryachev +27 more
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Regulation of the Neuron-specific Ras GTPase-activating Protein, synGAP, by Ca2+/Calmodulin-dependent Protein Kinase II [PDF]
, 2004 synGAP is a neuron-specific Ras GTPase-activating protein found in high concentration in the postsynaptic density fraction from mammalian forebrain. Proteins in the postsynaptic density, including synGAP, are part of a signaling complex attached to the ...
Kennedy, Mary B. +2 more
core +1 more source
Membrane curvature sensing of the lipid-anchored K-Ras small GTPase
Life Science Alliance, 2019 Proteolipid nanoassemblies of K-Ras and lipids in the plasma membrane sense changing membrane curvature architecture and convert mechanical perturbations to mitogenic signaling.
Hong Liang +12 more
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