Results 291 to 300 of about 8,056,792 (385)

Branched‐Chain α Keto‐Acid Dehydrogenase Kinase‐Mediated AKT Phosphorylation Promotes RCC Tumorigenesis and Drug Resistance

Advanced Science, EarlyView.
This study identifies a novel oncogenic role and a previously unrecognized phosphorylation substrate of BCKDK in RCC, wherein it promotes tumor progression and drug resistance through AKT phosphorylation at both Thr308 and Ser473 sites and activation of AKT/mTOR and AKT/ABCB1 signaling pathways, offering a promising prognostic marker and therapeutic ...
Qin Tian, Jinxiang Wang, Qiji Li, Yangruiyu Liu, Yanping Chen, Jiacheng Feng, Zi‐Ning Lei, Harsh Patel, Chao‐Yun Cai, Yuzhi Xu, Chuntao Quan, Lingyan Fei, Zexiu Xiao, Shuo Fang, Tianxin Lin, Zhe‐Sheng Chen, Yuchen Liu, Leli Zeng, Yihang Pan   +18 more
wiley   +1 more source

Integrated transcriptome and metabolome analyses unraveled critical roles of small intestine during the weaning period of Vespertilio sinensis. [PDF]

BMC Genomics
Li Z, Guo W, Chu Y, Tan X, Wang H, Feng J, Liu T.   +6 more
europepmc   +1 more source

Somatic mutation of CDKN1B in small intestine neuroendocrine tumors

Nature Genetics, 2013
J. Francis, Adam Kiezun, A. Ramos, S. Serra, C. Pedamallu, Z. Qian, M. Banck, Rahul Kanwar, A. Kulkarni, A. Karpathakis, Veronica E. Manzo, Tanupriya Contractor, Juliet Philips, E. Nickerson, Nam Pho, Susanne M. Hooshmand, L. Brais, M. Lawrence, Trevor J Pugh, A. McKenna, A. Sivachenko, K. Cibulskis, S. Carter, A. Ojesina, S. Freeman, Robert Jones, Douglas Voet, G. Saksena, D. Auclair, R. Onofrio, Erica Shefler, C. Sougnez, J. Grimsby, L. Green, N. Lennon, T. Meyer, M. Caplin, D. Chung, A. Beutler, S. Ogino, C. Thirlwell, R. Shivdasani, S. Asa, C. Harris, G. Getz, M. Kulke, M. Meyerson   +46 more
semanticscholar   +1 more source

Acod1 Promotes PAD4 Ubiquitination via UBR5 Alkylation to Modulate NETosis and Exert Protective Effects in Sepsis

Advanced Science, EarlyView.
In this study, Acod1 knockout in CLP mice significantly increases peripheral blood NET levels, exacerbating inflammation, organ damage, and reducing survival. Further research shows that UBR5 interacts with PAD4, a key NET formation protein. Acod1/itaconate (ITA) enhances the enzymatic activity of UBR5 by alkylating the Cys2768 site, promoting the K48 ...
Huifan Liu, Guoqing Jing, Shujuan Wu, Min Yuan, Yingyue Dong, Xue Chen, Huimin Zhou, Hailong Gong, Jing Zuo, Xiaojing Wu, Xuemin Song   +10 more
wiley   +1 more source

Immune-epithelial-stromal networks define the cellular ecosystem of the small intestine in celiac disease. [PDF]

Nat Immunol
FitzPatrick MEB, Antanaviciute A, Dunstan M, Künnapuu K, Trzupek D, Provine NM, Dooley K, Zhang JY, Irwin SL, Garner LC, Pernes JI, Ferreira RC, Sasson SC, Aschenbrenner D, Agarwal D, Rodrigues A, Howarth L, Brain O, Ruane D, Soilleux E, Teichmann SA, Dendrou CA, Simmons A, Uhlig HH, Todd JA, Klenerman P.   +25 more
europepmc   +1 more source

Sensitivity of the small intestine

, 1948
C. B. B. Downman, B. A. McSwiney, C. C. N. Vass   +2 more
openalex   +2 more sources

Tailoring a Functional Synthetic Microbial Community Alleviates Fusobacterium nucleatum‐infected Colorectal Cancer via Ecological Control

Advanced Science, EarlyView.
The bottom‐up strategy based on multiomics data is used for the SynCom design, and it successfully inhibited F. nucleatum growth and achieved stable colonization in vivo. In addition, it promoted tryptophan metabolism and secondary bile acid conversion, reduced lipid accumulation, relieved microbiome disorder, decreased inflammatory reaction, and ...
Zhongkun Zhou, Mengyue Yang, Hong Fang, Baizhuo Zhang, Yunhao Ma, Yongyuan Li, Yingjie Liu, Zeying Cheng, Yuanchun Zhao, Zhenzhen Si, Hongmei Zhu, Peng Chen   +11 more
wiley   +1 more source

Serum Visfatin/eNAMPT as a Biomarker in Pancreatic and Small Intestine Neuroendocrine Tumors: A Cross-Sectional Study and Future Perspectives. [PDF]

Cancers (Basel)
Komarnicki P, Maciejewski A, Musiałkiewicz J, Czupińska M, Mastorakos G, Ruchała M, Gut P.   +6 more
europepmc   +1 more source

PRIMARY CARCINOMA OF THE SMALL INTESTINE IN AN OCTOGENARIAN

, 1925
A Primrose
openalex   +2 more sources