Results 121 to 130 of about 5,657,410 (310)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Camera trap method effectively identifies small mammal species in forested habitats

open access: yesCalifornia Fish and Wildlife Journal
Effective survey methods to detect small mammal species are often needed to develop conservation and management plans in forested ecosystems. The ability to use non-invasive methods to identify small mammal species in the field is particularly useful as ...
Barbara Clucas, Sydney L. McCluskey
doaj   +1 more source

R code and data - Small mammal diversity regressions

open access: yes
This is the R code for the linear models assessing the relationship between vegetation diversity or richness and small mammal diversity in the Minor and Eichholz small mammal community JOWM publication.
Ashlee Minor (17821799)
core   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan   +7 more
wiley   +1 more source

Flexural Behavior of 3D‐Printed Porous Bouligand‐Structured Polymers: Influence of Pitch Angle and Porosity

open access: yesAdvanced Engineering Materials, EarlyView.
This study examines how helicoidal architectures with different porosities respond to bending. Adjusting layer angle and spacing in 3D‐printed polymers reveals clear tradeoffs between stiffness, strength, and energy absorption. Experiments and simulations highlight designs that distribute stress effectively, offering pathways for optimizing lightweight
Praveenkumar Subhash Patil   +2 more
wiley   +1 more source

Diversity and Habitat Associations of Subarctic Small Mammal Assemblages in the Yukon’s Tombstone Territorial Park

open access: yesDiversity
Small mammals play a central role in northern ecosystems, yet their diversity and habitat associations remain poorly documented in the subarctic mountains of northwestern Canada.
Thomas S. Jung
doaj   +1 more source

Myodes glareolus - 71831, Zoological collection of the Mammal Research Institute, PAS

open access: yes
Myodes glareolus (Bank vole) from Zoological collection of the Mammal Research Institute, PAS. Collected 1968-02-23, in: Białowieża National Park, Poland.
Mammal Research Institute, Polish Academy of Sciences
core   +1 more source

Edible Cuttlefish Ink: Complex Chemistry, Structure, and Electrical Response

open access: yesAdvanced Engineering Materials, EarlyView.
An integrated approach of chemistry‐structure‐electrical properties is used to assess the potential of edible cuttlefish ink as a bio‐based conductive ink for printable electronics. Chromatography and Neutron Activation Analysis reveal a fascinating molecular and elemental diversity.
Camille Bour‐Cardinal   +5 more
wiley   +1 more source

Myodes glareolus - 2353, Zoological collection of the Mammal Research Institute, PAS

open access: yes
Myodes glareolus (Bank vole) from Zoological collection of the Mammal Research Institute, PAS. Collected 1953-07-16, in: Białowieża National Park, Poland.
Mammal Research Institute, Polish Academy of Sciences
core   +1 more source

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