Results 31 to 40 of about 5,657,410 (310)

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Prairie small mammal survey 1992

open access: yes, 2022
Student paper "An assessment of very small mammal population fluctuation in tallgrass prairies, Lake Okoboji Region, Dickinson County Iowa, as indicated by short term live trapping" by Paula Thorson written in July ...
Iowa Lakeside Laboratory Dark Data (10959897)
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Appendix C. Small-mammal trapping methodology.

open access: yes, 2016
Small-mammal trapping ...
Robert J. Fletcher Jr. (431571)   +2 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Disentangling the Effects of Climate and Land Uses on Small Mammals in Agroecosystems of NE Spain

open access: yesDiversity
We analyzed the two main drivers (climate and land uses) shaping the composition of small mammal communities at 16 localities situated in the confluence of the Mediterranean and Eurosiberian regions (Barcelona, Spain).
Ignasi Torre   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Advancing bone health evaluation in Hermann’s tortoises (Testudo hermanni) using spectral detector computed tomography

open access: yesFrontiers in Veterinary Science
IntroductionMetabolic bone disease (MBD) is a common disorder in captive chelonians. Early diagnosis is challenging due to non-specific clinical signs, normal blood values in early stages, and limited sensitivity of radiographs.
A. Hörmann   +5 more
doaj   +1 more source

Leptospiral carriage in small wild mammal species.

open access: yes, 2019
Leptospiral carriage in small wild mammal species.
Ashutosh Verma (36178)   +13 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

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