Results 1 to 10 of about 10,015,665 (250)

Small Molecule Inhibitors of CRM1 [PDF]

Frontiers in Pharmacology, 2020
The transport through the nuclear pore complex is used by cancer cells to evade tumor-suppressive mechanisms. Several tumor-suppressors have been shown to be excluded from the cell nucleus in cancer cells by the nuclear export receptor CRM1 and abnormal expression of CRM1 is oncogenic.
Bibiana I. Ferreira, Bibiana I. Ferreira, Bibiana I. Ferreira, Bastien Cautain, Bastien Cautain, Inês Grenho, Inês Grenho, Inês Grenho, Wolfgang Link   +8 more
openaire   +9 more sources

3CLpro inhibitors: DEL-based molecular generation

Frontiers in Pharmacology, 2022
Molecular generation (MG) via machine learning (ML) has speeded drug structural optimization, especially for targets with a large amount of reported bioactivity data.
Feng Xiong, Honggui Xu, Mingao Yu, Xingyu Chen, Zhenmin Zhong, Yuhan Guo, Meihong Chen, Huanfang Ou, Jiaqi Wu, Anhua Xie, Jiaqi Xiong, Linlin Xu, Lanmei Zhang, Qijian Zhong, Liye Huang, Zhenwei Li, Tianyuan Zhang, Feng Jin, Xun He   +18 more
doaj   +1 more source

Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation

Theranostics, 2023
Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria through an autophagy mechanism, thus maintaining mitochondria and intracellular homeostasis.
Yingying Lu, Zhijia Li, Shuangqian Zhang, Tongtong Zhang, Yanjun Liu, Lan Zhang   +5 more
semanticscholar   +1 more source

Small molecule metabolites: discovery of biomarkers and therapeutic targets

Signal Transduction and Targeted Therapy, 2023
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite signatures that have close proximity to subject’s phenotypic informative dimension,
Shi Qiu, Ying Cai, Hong Yao, Chunsheng Lin, Yiqiang Xie, Songqi Tang, Aihua Zhang   +6 more
semanticscholar   +1 more source

Discovery of TIGIT inhibitors based on DEL and machine learning

Frontiers in Chemistry, 2022
Drug discovery has entered a new period of vigorous development with advanced technologies such as DNA-encoded library (DEL) and artificial intelligence (AI).
Feng Xiong, Mingao Yu, Honggui Xu, Zhenmin Zhong, Zhenwei Li, Yuhan Guo, Tianyuan Zhang, Zhixuan Zeng, Feng Jin, Xun He   +9 more
doaj   +1 more source

Advances and Challenges in Small-Molecule DNA Aptamer Isolation, Characterization, and Sensor Development.

Angewandte Chemie, 2021
Aptamers are short oligonucleotides isolated in vitro from randomized libraries that can bind to specific molecules with high affinity, and offer a number of advantages relative to antibodies as biorecognition elements in biosensors.
Haixiang Yu, Obtin Alkhamis, Juan Canoura, Yingzhu Liu, Yi Xiao   +4 more
semanticscholar   +1 more source

Utilizing Molecular Simulations to Examine Nanosuspension Stability

Pharmaceutics, 2023
Drug nanosuspensions offer a promising approach to improve bioavailability for poorly soluble drug candidates. Such formulations often necessitate the inclusion of an excipient to stabilize the drug nanoparticles. However, the rationale for the choice of
Andrew P. Latham, Elizabeth S. Levy, Benjamin D. Sellers, Dennis H. Leung   +3 more
doaj   +1 more source

Natural and Man-Made Cyclic Peptide-Based Antibiotics

Antibiotics, 2022
In recent years, an increasing number of drug-resistant bacterial strains have been identified due to the abuse of antibiotics, which seriously threatens human and animal health. Antimicrobial peptides (AMPs) have become one of the most effective weapons
Shian Lai, Quan Zhang, Lin Jin
doaj   +1 more source

Copper-Catalyzed Synthesis of Axially Chiral Biaryls with Diaryliodonium Salts as Arylation Reagents

Molecules, 2021
NOBIN and BINAM derivatives harboring biaryl frameworks are recognized as a class of important atropisomers with versatile applications. Here, we present an efficient synthetic route to access such compounds through copper-catalyzed domino arylation of N-
Ji-Wei Zhang, Shao-Hua Xiang, Shaoyu Li, Bin Tan   +3 more
doaj   +1 more source

Small molecule inhibitors targeting the cancers

MedComm, 2022
Compared with traditional therapies, targeted therapy has merits in selectivity, efficacy, and tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer.
Gui-Hong Liu, Tao Chen, Xin Zhang, Xuelei Ma, Hua-Shan Shi   +4 more
semanticscholar   +1 more source