Results 101 to 110 of about 10,015,764 (349)
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Development of a NanoBRET assay for evaluation of 14-3-3σ molecular glues
SLAS DiscoveryWe report the development of a 384-well formatted NanoBRET assay to characterize molecular glues of 14-3-3/client interactions in living cells. The seven isoforms of 14-3-3 are dimeric hub proteins with diverse roles including transcription factor ...
Holly R. Vickery +3 more
doaj
Sedimentation coefficients of small molecules: methods of measurement based on the refractive-index gradient curve. The sedimentation coefficient of polyglucose A [PDF]
, 1953 Robert L. Baldwin
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FEBS Letters, EarlyView.Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel +2 more
wiley +1 more source
The biosynthesis of kojic acid. 3. The incorporation of labelled small molecules into kojic acid [PDF]
, 1953 H. R. V. Arnstein, Ronald Bentley
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Small molecule immunomodulation: the tumor microenvironment and overcoming immune escape
Journal of Immunotherapy for Cancer, 2019 Immunotherapy has led to a paradigm shift in the treatment of many advanced malignancies. Despite the success in treatment of tumors like non-small cell lung cancer (NSCLC) and melanoma, checkpoint inhibition-based immunotherapy has limitations.
A. Osipov +3 more
semanticscholar +1 more source
FEBS Letters, EarlyView.To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche +2 more
wiley +1 more source
Determination of the Effective Hydrodynamic Radii of Small Molecules by Viscometry [PDF]
, 1961 Stanley G. Schultz, A. K. Solomon
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Small-molecule catalysis [PDF]
Nature, 2008 Joshua Finkelstein, Andrew Mitchinson
openaire +3 more sources
FEBS Letters, EarlyView.Most MmpLs transport lipids and glycolipids of the complex mycomembrane of mycobacteria. This study shows that MmpL10 from Mycobacterium smegmatis, the transporter of the trehalose polyphosphate precursor, harbors a coiled‐coil‐like extension. Biochemical and electron microscopy studies demonstrate that the coiled‐coil enables MmpL10 to trimerize.
Julie Couston +7 more
wiley +1 more source