Results 141 to 150 of about 2,196,436 (350)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

MA-[D-Leu-4]-OB3, a small molecule synthetic peptide leptin mimetic, improves episodic memory, and reduces serum levels of tumor necrosis factor-alpha and neurodegeneration in mouse models of Type 1 and Type 2 Diabetes Mellitus

, 2020
Zall Hirschstein, Gautam R Vanga, Guirong Wang, Zachary M. Novakovic, Patricia Grasso   +4 more
openalex   +2 more sources

COMPLEXES OF SMALL CHIRAL MOLECULES: PROPYLENE OXIDE AND 3-BUTYN-2OL [PDF]

, 2017
C. D. West, Brooks H. Pate, Ellie Coles, Luca Evangelisti   +3 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Viscoelastic behavior of polymers at long times seventh semiannual report, period ending 31 oct. 1964 [PDF]

Polymer behavior in cross linked systems in rubbery region, response of linear amorphous polymers, and viscoelasticity of nonpolar small molecule compound at glass ...
Plazek, D. J.
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Discovery of N-(3-Fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the First Small Molecule Motilin Receptor Agonist Clinical Candidate

, 2009
Susan M. Westaway, Samantha L. Brown, Stephen C. M. Fell, Christopher N. Johnson, David T. MacPherson, Darren J. Mitchell, James W. Myatt, Steven J. Stanway, Jon T. Seal, Geoffrey Stemp, Mervyn Thompson, Kirk Lawless, Fiona C. McKay, Alison I. Muir, Jonathan M. Barford, Chermaine Cluff, Sadhia R. Mahmood, Kim L. Matthews, Shiyam Mohamed, Beverley Smith, Alexander J. Stevens, Victoria J. Bolton, Emma M. Jarvie, Gareth J. Sanger   +23 more
openalex   +1 more source

1104 High-throughput small-molecule and RNAi screens identify Aurora kinase B inhibitors as a novel treatment for Merkel cell carcinoma [PDF]

, 2018
Tara Gelb, Daniel J. Urban, Angela Coxon, Berkley E. Gryder, Yuan Xiao, Rachael Glavin, Sirisha Chakka, O. Lee, Min Shen, Madhu Lal‐Nag, Matthew D. Hall, Isaac Brownell   +11 more
openalex   +1 more source

DMA, a Small Molecule, Increases Median Survival and Reduces Radiation-Induced Xerostomia via the Activation of the ERK1/2 Pathway in Oral Squamous Cell Carcinoma [PDF]

, 2022
Palak Parashar, Monoj Kumar Das, Pragya Tripathi, Tejinder Kataria, Deepak Gupta, Deepak Sarin, Puja Panwar Hazari, Vibha Tandon   +7 more
openalex   +1 more source