Results 171 to 180 of about 2,196,436 (350)

Tritium Labeling of Neuromedin S by Conjugation with [3H]N‑Succinimidyl Propionate

ACS Omega, 2023
Martin R. Edelmann, Johannes Erny, Wolfgang Guba, Markus Hierl   +3 more
doaj   +1 more source

Targeting of wnt signalling pathway by small bioactive molecules for the treatment of Alzheimer’s disease [PDF]

Ankumoni Dutta, Pallab Bhattacharya, Pavitra Chutia, Anupom Borah   +3 more
openalex   +1 more source

Small Molecule [PDF]

, 2020
openaire   +1 more source

Small molecule: large hopes [PDF]

Internal Medicine Journal, 2001
J, Szer, G J, Lieschke
openaire   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Engineering a colorimetric yeast-based assay to detect small molecules in the gastrointestinal system [PDF]

Louis Dacquay, Bana Samman, Matthew P. Newman, Dana J. Philpott, David R. McMillen   +4 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Unveiling Nonadiabatic Pathways in Small Molecule Activation: Dinuclear Uranium‐Mediated H ₂ and N ₂ Bond Cleavage [PDF]

Liangliang Wu, Xiai Zhang, Xiaoyan Cao, Wei‐Hai Fang, Michael Dolg, Xuebo Chen   +5 more
openalex   +1 more source

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Progress in Small Molecule Drug Development [PDF]

, 2010
Praveen P. N. Rao, Saad N Kabir, Tarek Mohamed   +2 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source