Results 11 to 20 of about 10,015,764 (349)
Molecules, 2021 Coumarins and 2H-pyran derivatives are among the most commonly found structural units in natural products. Therefore, the introduction of 2H-pyran moiety into the coumarin structural unit, i.e., dihydrocoumarin-fused dihydropyranones, is a potentially ...
Jun-Lin Li +5 more
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Anti-inflammatory properties of uvaol on DSS-induced colitis and LPS-stimulated macrophages
Chinese Medicine, 2020 Background Apocynum venetum leaves are used as a kind of phytomedicine and the main ingredient in some traditional Chinese medicine products for the relief of colitis. To understand the bioactive constituents of A.
Shi-yun Du +11 more
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Proteasome Activation by Small Molecules [PDF]
Cell Chemical Biology, 2017 Drugs that increase 26S proteasome activity have potential therapeutic applications in the treatment of neurodegenerative diseases. A chemical genetics screen of over 2,750 compounds using a proteasome activity probe as a readout in a high-throughput live-cell fluorescence-activated cell sorting-based assay revealed more than ten compounds that ...
Jannie Borst +15 more
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Frontiers in Pharmacology, 2022 Acinetobacter baumannii is one of the most dangerous opportunistic pathogens in the global health care setup. Its drug resistance and biofilm-forming capability are often associated with chronic infections that are difficult to treat.
Qianlin Meng +5 more
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Dalton Transactions, 2016 Welcome to this themed issue of Dalton Transactions entitled “Small molecule activation”.
MILANI, Barbara +3 more
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Synthesis, Characterization, and in vivo Evaluation of a Novel Potent Autotaxin-Inhibitor
Frontiers in Pharmacology, 2022 The autotaxin-lysophosphatidic acid (ATX-LPA) signaling pathway plays a role in a variety of autoimmune diseases, such as rheumatoid arthritis or neurodegeneration.
Daniel Hunziker +19 more
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Förster resonance energy transfer (FRET)-based small-molecule sensors and imaging agents.
Chemical Society Reviews, 2020 In this tutorial review, we will explore recent advances in the construction and application of Förster resonance energy transfer (FRET)-based small-molecule fluorescent probes.
Luling Wu +9 more
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Small Molecule Inhibitors of CXCR4 [PDF]
Theranostics, 2013 CXCR4 is a G-protein-coupled receptor involved in a number of physiological processes in the hematopoietic and immune systems. The SDF-1/CXCR4 axis is significantly associated with several diseases, such as HIV, cancer, WHIM syndrome, rheumatoid arthritis, pulmonary fibrosis and lupus.
Debnath B +4 more
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CHIMIA, 2018 A concise asymmetric synthesis has been developed to prepare idasanutlin, a small molecule MDM2 antagonist. Idasanutlin is currently being investigated as a potential treatment for various solid tumors and hematologic malignancies.
Dan Fishlock +8 more
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Small Molecules for Psoriasis [PDF]
Seminars in Cutaneous Medicine and Surgery, 2016 Acitretin is an older, oral, non-immunosuppressive medication for the treatment of psoriasis. Tofacitinib is an oral Janus kinase inhibitor that has been studied for use in psoriasis. Each offers efficacy in certain settings and patient types but carries substantial safety risks.
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