Results 11 to 20 of about 2,196,436 (350)
Small molecule activation [PDF]
Dalton Transactions, 2016 The activation of small molecules has become an increasingly popular area of research over the last years, and there are many reasons to be captivated by this fascinating ...
Albrecht, Martin +3 more
core +5 more sources
Emerging Small Molecule Drugs [PDF]
, 2014 Dyslipidaemia is a major risk factor for cardiovascular diseases. Pharmacological lowering of LDL-C levels using statins reduces cardiovascular risk. However, a substantial residual risk persists especially in patients with type 2 diabetes mellitus.
Colin, Sophie +3 more
openaire +2 more sources
De novo design of a homo-trimeric amantadine-binding protein. [PDF]
, 2019 The computational design of a symmetric protein homo-oligomer that binds a symmetry-matched small molecule larger than a metal ion has not yet been achieved.
Adams +36 more
core +2 more sources
Synthesis, Characterization, and in vivo Evaluation of a Novel Potent Autotaxin-Inhibitor
Frontiers in Pharmacology, 2022 The autotaxin-lysophosphatidic acid (ATX-LPA) signaling pathway plays a role in a variety of autoimmune diseases, such as rheumatoid arthritis or neurodegeneration.
Daniel Hunziker +19 more
doaj +1 more source
A photoactivatable small molecule probe for the in vivo capture of polyketide intermediates [PDF]
, 2019 A photolabile carba(dethia) malonyl N‐acetylcysteamine derivative was devised and prepared for the trapping of biosynthetic polyketide intermediates following light activation.
Jenkins, Robert +2 more
core +1 more source
CHIMIA, 2018 A concise asymmetric synthesis has been developed to prepare idasanutlin, a small molecule MDM2 antagonist. Idasanutlin is currently being investigated as a potential treatment for various solid tumors and hematologic malignancies.
Dan Fishlock +8 more
doaj +1 more source
Application of Transition Metal Catalysis to Small Molecule Synthesis [PDF]
, 2006 Over the past decade, transition metal catalysis has developed into a new field in organic synthesis, enabling numerous synthetic transformations that were previously not feasible.
Morrill, Christie
core +1 more source
Brain Research Bulletin, 2022 Beta-amyloid protein (Aβ) is one of the most important pathogenic factors of Alzheimer’s disease (AD). N-linoleyltyrosine (NITyr) was synthesized in our laboratory and exerted neuroprotective effects in APP/PS1 transgenic mice in previous reports.
Yi Zhou +8 more
doaj +1 more source
Small molecule induced reactivation of mutant p53 in cancer cells [PDF]
, 2013 The p53 cancer mutant Y220C is an excellent paradigm for rescuing the function of conformationally unstable p53 mutants because it has a unique surface crevice that can be targeted by small-molecule stabilizers.
Adams +58 more
core +2 more sources
Drug Delivery, 2019 The lipophilic prodrug of hydrophobic drugs with well-designed molecular structures can form stable pure prodrug nanoparticles (NPs), but rapid NPs aggregation in plasma greatly restricted their direct use for intravenous chemotherapy.
Jun Zeng +9 more
doaj +1 more source