Results 211 to 220 of about 10,015,764 (349)

Understanding the role of small-molecule therapeutics for snake envenoming. [PDF]

EBioMedicine
Silva A, Isbister G.
europepmc   +1 more source

A small-angle neutron scattering study of nonionic surfactant molecules at the water–oil interface: Area per molecule, microemulsion domain size, and rigidity [PDF]

, 1997
Thomas Sottmann, R. Strey, S. H. Chen
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Generation and validation of a novel multitarget small molecule in glioblastoma. [PDF]

Cell Death Dis
Artetxe-Zurutuza A, Iturrioz-Rodriguez N, Elizazu J, Toledano-Pinedo M, Porro-Pérez A, De Goñi I, Elua-Pinin A, Schäker-Hübner L, Azkargorta M, Elortza F, Iriepa I, Lòpez-Muñoz F, Moncho-Amor V, Hansen FK, Sampron N, Marco-Contelles JL, Matheu A.   +16 more
europepmc   +1 more source

Brain drug delivery of small molecules using immunoliposomes [PDF]

, 1996
Jörg Huwyler, Dafang Wu, William M. Pardridge   +2 more
openalex   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Discovery of an ApoE4-targeted small-molecule SirT1 enhancer for the treatment of Alzheimer's disease. [PDF]

Sci Rep
Campagna J, Chandra S, Teter B, Cohn W, Pham J, Kim YS, Jagodzinska B, Vadivel K, Alam P, Bilousova T, Young M, Elias C, Marcucci J, Flacau I, Jackman A, Padder S, Wi D, Zhu C, Spilman P, Jung ME, Bredesen DE, John V.   +21 more
europepmc   +1 more source

Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors [PDF]

, 1999
Shintaro Nakashima, Kenji Morinaka, Shinya Koyama, Masahiro Ikeda, Michiko Kishida, Katsuya Okawa, Akihiro Iwamatsu, Shosei Kishida, Akira Kikuchi   +8 more
openalex   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Chaperone overexpression boosts heterologous small molecule production in Saccharomyces cerevisiae. [PDF]

Microb Cell Fact
Vestergaard AM, Nurani W, Cachera P, Mortensen UH.   +3 more
europepmc   +1 more source