Results 231 to 240 of about 2,196,436 (350)

Small Molecule Protease Inhibitors as Model Peptidomimetics. [PDF]

Pharmaceuticals (Basel)
Gomez-Gutierrez P, Perez JJ.
europepmc   +1 more source

Targeted Genetic and Small Molecule Disruption of N-Ras Caax Cleavage Alters its Localization and Oncogenic Potential

Emily R. Hildebrandt, Shaneela A. Hussain, Michelle A. Sieburg, Rajani Ravishankar, Nadeem Asad, Sangram Gore, Takahiro Ito, James L. Hougland, Timothy M. Dore, Walter K. Schmidt   +9 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

New Approach for Targeting Small-Molecule Candidates for Intrinsically Disordered Proteins. [PDF]

Methods Protoc
Senćanski M.
europepmc   +1 more source

Design of a Bioactive Small Molecule That Targets the Myotonic Dystrophy Type 1 RNA via an RNA Motif–Ligand Database and Chemical Similarity Searching

, 2012
Raman Parkesh, Jessica L. Childs‐Disney, Masayuki Nakamori, Amit Kumar, Eric T. Wang, Thomas J. Wang, Jason W. Hoskins, Tuan Anh Tran, David E. Housman, Charles A. Thornton, Matthew D. Disney   +10 more
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Development of small molecule inhibitors of ECM collagen secretion. [PDF]

RSC Med Chem
Mancini RS, Bissey PA, Massignan L, Mane V, Weaver DF, Yip KW, Liu FF, Reed MA.   +7 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A pipeline for screening small molecule-enhanced protein stability in a bacterial orphan receptor. [PDF]

Protein Sci
Siclari JJ, Favaro DC, Huang RH, Gardner KH.   +3 more
europepmc   +1 more source

Synthesis, optical properties, theoretical calculations, and related applications of small molecule fluorescent probes

Jinghua Zhang, Yue Tang, Xiaoqiang Tong, Qichuan Duan, Jin Shi, Jun Zheng, Guoliang Xie, Qin Du, Shangrong Zhang, Dejian Huang, Feng Jin   +10 more
openalex   +1 more source