Results 251 to 260 of about 10,015,764 (349)

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Activation of pro-survival autophagy by a small molecule promoting p62 oligomerisation

Panek J, Sun C, Kataura T, Fielder E, Booth L, Yue W, Richardson G, Reynisson J, Sarkar S, Korolchuk VI.   +9 more
europepmc   +1 more source

Efficient Crystallization of Apo Sirt2 for Small-Molecule Soaking and Structural Analysis of Ligand Interactions. [PDF]

J Med Chem
Friedrich F, Schiedel M, Swyter S, Zhang L, Sippl W, Schutkowski M, Einsle O, Jung M.   +7 more
europepmc   +1 more source

Biodistribution of a radiolabelled monoclonal antibody NY3D11 recognizing the neural cell adhesion molecule in tumour xenografts and patients with small-cell lung cancer

, 1998
D Ornadel, JA Ledermann, K Eagle, RB Pedley, G Boxer, Simon E. Ward, Yemi Olabiran, J. Bomanji   +7 more
openalex   +1 more source

Alkyl Chain Tuning of Small Molecule Acceptors for Efficient Organic Solar Cells

, 2019
Kui Jiang, Qingya Wei, J. Lai, Zhengxing Peng, Ha Kyung Kim, Jun Yuan, L. Ye, H. Ade, Y. Zou, H. Yan   +9 more
semanticscholar   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Harnessing Molecular Recognition for Small-Molecule-Mediated Reversible Photochemical Control Over mRNA Translation. [PDF]

Angew Chem Int Ed Engl
Parmar S, Tenney L, Liang X, Routzahn JT, Sibley CD, Schneekloth JS.   +5 more
europepmc   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Coverage bias in small molecule machine learning. [PDF]

Nat Commun
Kretschmer F, Seipp J, Ludwig M, Klau GW, Böcker S.   +4 more
europepmc   +1 more source