Results 281 to 290 of about 2,196,436 (350)

Small-molecule and peptide inhibitors of m6A regulators. [PDF]

Front Oncol
Liu X, Kan X.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Overcoming cancer drug resistance through small-molecule targeting of HSP90 and HSP70. [PDF]

Cancer Drug Resist
Cai RD, Lin MJ, Ye QM.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Structure-activity relationships of hydrophobic small molecule irreversible inhibitors of tissue transglutaminase. [PDF]

RSC Med Chem
Wallace DA, Tribe S, Navals P, Bi C, Sharma T, Keillor JW.   +5 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Proteomic Insights into Small Molecule Modulation on Caudal Fin Regeneration in Zebrafish. [PDF]

ACS Omega
Anusha PV, Tewari S, Philip C, Arvind A, Iyoob I, Idris MM.   +5 more
europepmc   +1 more source