Results 21 to 30 of about 2,196,436 (350)
A DFT study of the NO adsorption on Pdn (n = 1–4) clusters [PDF]
, 2011 We report a density-functional study of some properties of the adsorption process of the NO molecule on small palladium clusters (n = 1–4). The interaction between NO and the Pdn clusters is studied on various adsorption sites.
Alexiev, Valentin +6 more
core +3 more sources
Journal of Inborn Errors of Metabolism and Screening, 2016 Lysosomal storage disorders are rare genetic disorders due to deficient lysosomal activity, which leads to progressive accumulation of nonmetabolized substrates. Patient’s clinical outcomes have significantly improved since the advent of enzyme replacement therapy, even though this therapeutic approach presents important limitations, such as immune ...
B. Lu, A. Atala
openaire +3 more sources
Drug Delivery, 2019 The therapeutic outcome of chemotherapy is limited, although it is still the preferent strategy for cancer therapy. By regulation of tumor microenvironment and introduction of another therapeutic manner for combination therapy can enhance the anticancer ...
Xiao Yuan +4 more
doaj +1 more source
Pharmaceutics, 2023 Intraperitoneal injection of dihydromyricetin (DMY) has shown promising potential in the treatment of alcoholism. However, its therapeutic effect is limited due to its low solubility, poor stability, and high gut-liver first-pass metabolism, resulting in
Jianxia Dong +10 more
doaj +1 more source
Genome-scale architecture of small molecule regulatory networks and the fundamental trade-off between regulation and enzymatic activity [PDF]
, 2017 Metabolic flux is in part regulated by endogenous small molecules that modulate the catalytic activity of an enzyme, e.g., allosteric inhibition. In contrast to transcriptional regulation of enzymes, technical limitations have hindered the production of ...
Briars, Emma +6 more
core +2 more sources
Novel pharmacological maps of protein lysine methyltransferases: key for target deorphanization
Journal of Cheminformatics, 2018 Epigenetic therapies are being investigated for the treatment of cancer, cognitive disorders, metabolic alterations and autoinmune diseases. Among the different epigenetic target families, protein lysine methyltransferases (PKMTs), are especially ...
Obdulia Rabal +2 more
doaj +1 more source
Fractal scattering dynamics of the three-dimensional HOCl molecule [PDF]
, 2013 We compare the 2D and 3D classical fractal scattering dynamics of Cl and HO for energies just above dissociation of the HOCl molecule, using a realistic potential energy surface for the HOCl molecule and techniques developed to analyze 3D chaotic ...
Barr, Alex M. +3 more
core +1 more source
Gradient-Driven Molecule Construction: An Inverse Approach Applied to the Design of Small-Molecule Fixating Catalysts [PDF]
, 2014 Rational design of molecules and materials usually requires extensive screening of molecular structures for the desired property. The inverse approach to deduce a structure for a predefined property would be highly desirable, but is, unfortunately, not ...
Reiher, Markus, Weymuth, Thomas
core +1 more source
Small Molecule Condensin Inhibitors [PDF]
ACS Infectious Diseases, 2018 Condensins play a unique role in orchestrating the global folding of the chromosome, an essential cellular process, and contribute to human disease and bacterial pathogenicity. As such, they represent an attractive and as yet untapped target for diverse therapeutic interventions.
Hang Zhao +5 more
openaire +2 more sources
Pharmaceutics, 2022 The pharmaceutical industry has been challenged by the increasing number of poorly soluble drug candidates, resulting in significant issues with obtaining sufficient absorption and bioavailability, risk of exposure variability, and difficulties in ...
Dennis H. Leung
doaj +1 more source