Results 21 to 30 of about 10,015,764 (349)

Photon Upconversion in Small Molecules

Molecules, 2022
Upconversion (UC) is a process that describes the emission of shorter-wavelength light compared to that of the excitation source. Thus, UC is also referred to as anti-Stokes emission because the excitation wavelength is longer than the emission wavelength. UC materials are used in many fields, from electronics to medicine.
Dorota Bartusik-Aebisher, Mateusz Mielnik, Grzegorz Cieślar, Ewa Chodurek, Aleksandra Kawczyk-Krupka, David Aebisher   +5 more
openaire   +3 more sources

pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures

Journal of Medicinal Chemistry, 2015
Drug development has a high attrition rate, with poor pharmacokinetic and safety properties a significant hurdle. Computational approaches may help minimize these risks.
Douglas E. V. Pires, T. Blundell, D. Ascher   +2 more
semanticscholar   +1 more source

PEGylation of lipophilic SN38 prodrug with DSPE-mPEG2000 versus cremophor EL: comparative study for intravenous chemotherapy

Drug Delivery, 2019
The lipophilic prodrug of hydrophobic drugs with well-designed molecular structures can form stable pure prodrug nanoparticles (NPs), but rapid NPs aggregation in plasma greatly restricted their direct use for intravenous chemotherapy.
Jun Zeng, Chen Li, Xing Duan, Fuyue Liu, Anqin Li, Chunhan Luo, Li Jia, Yifang Gan, Lu Yan, Yaxin Zheng   +9 more
doaj   +1 more source

Preparation of Dihydromyricetin-Loaded Self-Emulsifying Drug Delivery System and Its Anti-Alcoholism Effect

Pharmaceutics, 2023
Intraperitoneal injection of dihydromyricetin (DMY) has shown promising potential in the treatment of alcoholism. However, its therapeutic effect is limited due to its low solubility, poor stability, and high gut-liver first-pass metabolism, resulting in
Jianxia Dong, Shu Wang, Jiamin Mao, Zhidan Wang, Shiying Zhao, Qiao Ren, Jialing Kang, Jing Ye, Xiaohong Xu, Yujin Zhu, Quan Zhang   +10 more
doaj   +1 more source

Hybrid manganese dioxide-bovine serum albumin nanostructure incorporated with doxorubicin and IR780 for enhanced breast cancer chemo-photothermal therapy

Drug Delivery, 2019
The therapeutic outcome of chemotherapy is limited, although it is still the preferent strategy for cancer therapy. By regulation of tumor microenvironment and introduction of another therapeutic manner for combination therapy can enhance the anticancer ...
Xiao Yuan, Yanlong Yin, Wang Zan, Xiyang Sun, Qian Yang   +4 more
doaj   +1 more source

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

Science Advances, 2019
Gingipains from Porphyromonas gingivalis drive Alzheimer’s pathology and can be blocked with small-molecule inhibitors. Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in the brain of Alzheimer’s disease patients.
S. Dominy, Casey C. Lynch, F. Ermini, M. Benedyk, A. Marczyk, A. Konradi, M. Nguyen, Ursula Haditsch, D. Raha, Christina Griffin, L. Holsinger, S. Arastu‐Kapur, S. Kaba, Alexander Lee, M. Ryder, B. Potempa, P. Mydel, A. Hellvard, K. Adamowicz, H. Hasturk, G. Walker, E. Reynolds, R. Faull, M. Curtis, M. Dragunow, J. Potempa   +25 more
semanticscholar   +1 more source

Sculpting the proteome with small molecules [PDF]

Nature Chemical Biology, 2014
The ubiquitin-proteasome system (UPS) pervades the biology of eukaryotes. Because it depends on the activity of hundreds of different enzymes and protein-protein interactions, the UPS provides many opportunities for selective modulation of the pathway with small molecules.
Daniel Finley, Randall W. King
openaire   +3 more sources

Novel pharmacological maps of protein lysine methyltransferases: key for target deorphanization

Journal of Cheminformatics, 2018
Epigenetic therapies are being investigated for the treatment of cancer, cognitive disorders, metabolic alterations and autoinmune diseases. Among the different epigenetic target families, protein lysine methyltransferases (PKMTs), are especially ...
Obdulia Rabal, Andrea Castellar, Julen Oyarzabal   +2 more
doaj   +1 more source

A simple generic method for analyzing water sensitive pinacol boronate compounds by hydrophilic interaction liquid chromatography

Journal of Chromatography Open, 2022
Pinacol boronates are widely used in the pharmaceutical and biomedical industries as primary building blocks for many chemical reactions, such as Suzuki coupling.
Lulu Dai, Joseph Gonzalez, Kelly Zhang
doaj  

Development of Nanosuspension Formulations Compatible with Inkjet Printing for the Convenient and Precise Dispensing of Poorly Soluble Drugs

Pharmaceutics, 2022
The pharmaceutical industry has been challenged by the increasing number of poorly soluble drug candidates, resulting in significant issues with obtaining sufficient absorption and bioavailability, risk of exposure variability, and difficulties in ...
Dennis H. Leung
doaj   +1 more source