Results 311 to 320 of about 2,196,436 (350)

Small Molecule PET-Radiopharmaceuticals

Current Pharmaceutical Design, 2014
This review describes several aspects required for the development of small molecule PET-tracers. Design and selection criteria are important to consider before starting to develop novel PET-tracers. Principles and latest trends in (11)C and (18)F-radiochemistry are summarized.
Elsinga, Philip H., Dierckx, Rudi A. J. O.   +1 more
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Small-molecule Arginase Inhibitors

Pharmaceutical Patent Analyst, 2013
Arginase is an enzyme that metabolizes L-arginine to L-ornithine and urea. In addition to its fundamental role in the hepatic ornithine cycle, it also influences the immune systems in humans and mice. Arginase participates in many inflammatory disorders by decreasing the synthesis of nitric oxide and inducing fibrosis and tissue regeneration.
Yan A, Ivanenkov, Nina V, Chufarova
openaire   +2 more sources

Shielding in Small Molecules

2007
The sections in this article are 1 Introduction 2 Electronic Hamiltonians for a Molecule in an Electromagnetic Field 3 Linear Response in Magnetic Fields 4 Biographical Sketches Related ...
P. Lazzeretti, M. Malagoli, ZANASI, Riccardo   +2 more
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Small molecules DNAmethyltransferasesinhibitors

MedChemComm, 2012
This review describes current knowledge concerning DNA methyltransferases (DNMT) biology and the two main classes of DNMT inhibtors.
Martinet, N., Michel, B.Y., Bertrand, P., Benhida, R.   +3 more
openaire   +2 more sources

Small Molecule CXCR3 Antagonists

Journal of Medicinal Chemistry, 2015
Chemokines and their receptors are known to play important roles in disease. More than 40 chemokine ligands and 20 chemokine receptors have been identified, but, to date, only two small molecule chemokine receptor antagonists have been approved by the FDA.
Stephen P, Andrews, Rhona J, Cox
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Small‐molecule AT2 receptor agonists

Medicinal Research Reviews, 2017
AbstractThe discovery of the first selective, small‐molecule ATR receptor (AT2R) agonist compound 21 (C21) (8) that is now extensively studied in a large variety of in vitro and in vivo models is described. The sulfonylcarbamate derivative 8, encompassing a phenylthiofen scaffold is the drug‐like agonist with the highest affinity for the AT2R reported ...
Mathias Hallberg, Colin Sumners, U. Muscha Steckelings, Anders Hallberg   +3 more
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Small Molecule Microarray: Functional-Group Specific Immobilization of Small Molecules

2010
Proteomic screening with small molecule microarrays can be a powerful tool in conjunction with various forward chemical genetics screening and high-throughput phenotype assays. Small molecule microarray screening can provide high quality information from the direct binding interaction between proteins of interest and a collection of small molecules in ...
Hyang Yeon, Lee, Seung Bum, Park
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Detecting Protein–Small Molecule Interactions Using Fluorous Small-Molecule Microarrays

2010
General binding assays involving microarrays of small molecules can be used to identify small molecule ligands for nearly any protein, even in the absence of knowledge about protein structure or function. Several suitable methods for manufacturing small molecule microarrays (SMMs) exist and different immobilization methods may be more or less ...
Arturo J, Vegas, Angela N, Koehler
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Small molecule signaling

Current Opinion in Microbiology, 2009
Jenal, U., Dorman, C. J.
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WWW small molecule modeling

SAR and QSAR in Environmental Research, 2002
Computational chemistry and molecular modeling sites have proliferated on the Internet's world wide web. This paper provides present links to some of the more most useful ones for small organic molecule modeling, and offering free resources.
openaire   +2 more sources