Results 321 to 330 of about 10,015,764 (349)

Small-Molecule Modulators of Toll-like Receptors.

Accounts of Chemical Research, 2020
ConspectusToll-like receptors (TLRs) are the "gatekeepers" of the immune system in humans and other animals to protect the host from invading bacteria, viruses, and other microorganisms. Since TLR4 was discovered as the receptor for endotoxin in the late
Yibo Wang, Shuting Zhang, Hongyuan Li, Hongshuang Wang, Tianshu Zhang, M. Hutchinson, H. Yin, Xiaohui Wang   +7 more
semanticscholar   +1 more source

Small Molecule PET-Radiopharmaceuticals

Current Pharmaceutical Design, 2014
This review describes several aspects required for the development of small molecule PET-tracers. Design and selection criteria are important to consider before starting to develop novel PET-tracers. Principles and latest trends in (11)C and (18)F-radiochemistry are summarized.
Philip H. Elsinga, Rudi Dierckx
openaire   +3 more sources

Mechanisms regulating PD-L1 expression in cancers and associated opportunities for novel small-molecule therapeutics

Nature Reviews Clinical Oncology, 2022
H. Yamaguchi, Jung-Mao Hsu, Wen-Hao Yang, M. Hung   +3 more
semanticscholar   +1 more source

Small Molecule Modulators of Transcription

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
openaire   +4 more sources

AI in small-molecule drug discovery: a coming wave?

Nature reviews. Drug discovery, 2022
Madura K P Jayatunga, Wen Xie, Ludwig F Ruder, Ulrik Schulze, C. Meier   +4 more
semanticscholar   +1 more source

Targeting RNA with Small Molecules

ChemBioChem, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +4 more sources

Inhibiting Inflammasomes with Small Molecules

2018
Modulation of inflammasomes has tremendous therapeutic potential and is hotly pursued by industry and academia alike. Indeed a growing number of patents are emerging to protect the intellectual property in valuable compound classes. This chapter focusses specifically on the suite of small-molecule NLRP3 inflammasome inhibitors published, as specific ...
openaire   +4 more sources

Small-molecule library screening by docking with PyRx.

Methods in molecular biology, 2015
S. Dallakyan, A. Olson
semanticscholar   +1 more source

Small molecule probes for targeting autophagy

Nature Chemical Biology, 2021
T. Whitmarsh-Everiss, Luca Laraia
semanticscholar   +1 more source

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Science, 2004
L. Vassilev, B. Vu, B. Graves, D. Carvajal, F. Podlaski, Z. Filipovic, Norman Kong, U. Kammlott, C. Lukacs, C. Klein, N. Fotouhi, E. A. Liu   +11 more
semanticscholar   +1 more source