Results 31 to 40 of about 10,015,764 (349)
Small molecule-induced polymerization triggers degradation of BCL6
Nature, 2020 Effective and sustained inhibition of non-enzymatic oncogenic driver proteins is a major pharmacological challenge. The clinical success of thalidomide analogues demonstrates the therapeutic efficacy of drug-induced degradation of transcription factors ...
Mikołaj Słabicki +20 more
semanticscholar +1 more source
A Small-Molecule Inhibitor of Lin28
ACS Chemical Biology, 2016 New discoveries in RNA biology underscore a need for chemical tools to clarify their roles in pathophysiological mechanisms. In certain cancers, synthesis of the let-7 microRNA tumor suppressor is blocked by an RNA binding protein (RBP) Lin28, which docks onto a conserved sequence in let-7 precursor RNA molecules and prevents their maturation.
Roos Martina +15 more
openaire +4 more sources
Emerging Small Molecule Drugs [PDF]
, 2014 Dyslipidaemia is a major risk factor for cardiovascular diseases. Pharmacological lowering of LDL-C levels using statins reduces cardiovascular risk. However, a substantial residual risk persists especially in patients with type 2 diabetes mellitus.
Giulia Chinetti-Gbaguidi +3 more
openaire +2 more sources
Drug Effect of Thulium(III)-Arsenazo III Complex on Herring Sperm DNA
Journal of Chemistry, 2018 To assess the potential cytostatic properties of the thulium(III)-arsenazo III complex as a probe of rare earth complex antitumor drugs, the interaction information of the thulium(III)-arsenazo III complex with DNA was obtained by using spectroscopy ...
Hongbo Li +5 more
doaj +1 more source
Small Molecule NF-κB Pathway Inhibitors in Clinic
International Journal of Molecular Sciences, 2020 Nuclear factor kappa B (NF-κB) signaling is implicated in all major human chronic diseases, with its role in transcription of hundreds of gene well established in the literature.
Venkataramanan Ramadass +2 more
semanticscholar +1 more source
eLife, 2017 Invasion of erythrocytes by Plasmodial merozoites is a composite process involving the interplay of several proteins. Among them, the Plasmodium falciparum Cysteine-Rich Protective Antigen (PfCyRPA) is a crucial component of a ternary complex, including ...
Paola Favuzza +16 more
doaj +1 more source
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
Nature, 2016 The most recent Ebola virus outbreak in West Africa, which was unprecedented in the number of cases and fatalities, geographic distribution, and number of nations affected, highlights the need for safe, effective, and readily available antiviral agents ...
Travis K Warren +61 more
semanticscholar +1 more source
Imaging small molecule-induced endosomal escape of siRNA
Nature Communications, 2020 Small interfering RNAs (siRNAs) are a new class of promising therapeutic molecules that can be used for sequence-specific downregulation of disease-causing genes.
Hampus Du Rietz +4 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 5-fluorouracil (5-FU) is one of the most widely used chemotherapy drugs for malignant tumors. However, intestinal mucositis caused by 5-FU is a severe dose-limiting toxic effect and even leads to treatment interruption.
Yi-fan Liao +18 more
doaj +1 more source
Designing Small Molecules for Biodegradability [PDF]
ChemInform, 2007 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Elizabeth Sommer +2 more
openaire +3 more sources