Results 41 to 50 of about 2,196,436 (350)

2013 REU Poster: Small Molecule Evolution: A Biomimetic Approach to Small Molecule Lead Generation and Optimization [PDF]

, 2013
Poster presentation at REU Summer's End Research Symposium, 2013, by REU participant Tiara Bloodworth, MassBay Community College - Aaron Beeler group, Dr.
Bloodworth, Tiara L.
core   +1 more source

Liability of a Surgeon for the Extension of an Authorized Operation [PDF]

, 1956
Polyunsaturated fatty acids modulate the voltage dependence of several voltage-gated ion channels, thereby being potent modifiers of cellular excitability.
Billman, Boland, Broomand, Broomand, Börjesson, Börjesson, Börjesson, Börjesson, Catterall, Clarke, DeCaen, DeCaen, Delemotte, Elinder, Elinder, Fredrik Elinder, Henrion, Hock, Hoshi, Hoshi, Hoshi, Imaizumi, Jensen, Kamb, Keynes, Long, McKay, McLennan, Moreno, Nina E. Ottosson, Papazian, Richieri, Sara I. Liin, Schmidt, Spector, Sun, Tao, Tigerholm, Vreugdenhil, Xiao, Xiao, Xu, Xu, Yang   +43 more
core   +2 more sources

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays. [PDF]

, 2020
Elevated cytoplasmic [Ca2+] is characteristic in severe skeletal and cardiac myopathies, diabetes, and neurodegeneration, and partly results from increased Ca2+ leak from sarcoplasmic reticulum stores via dysregulated ryanodine receptor (RyR) channels ...
Bers, Donald M, Cornea, Razvan L, Janicek, Kevyn A, Launikonis, Bradley S, Rebbeck, Robyn T, Singh, Daniel P, Thomas, David D   +6 more
core   +2 more sources

Survival for Children Diagnosed With Wilms Tumour (2012–2022) Registered in the UK and Ireland Improving Population Outcomes for Renal Tumours of Childhood (IMPORT) Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Improving Population Outcomes for Renal Tumours of childhood (IMPORT) is a prospective clinical observational study capturing detailed demographic and outcome data on children and young people diagnosed with renal tumours in the United Kingdom and the Republic of Ireland.
Naomi Ssenyonga, Angela Lopez‐Cortes, Reem Al‐Saadi, Suzanne Tugnait, Kristina Dzhuma, Catriona Duncan, Gordan Vujanic, Tanzina Chowdhury, Claudia Allemani, Michel P. Coleman, Kathy Pritchard‐Jones, the Children's Cancer and Leukaemia Group (CCLG) Renal Tumour Special Interest Group, Hugh Bishop, Anthony McCarthy, Pamela Kearns, Helen Rees, Amos Burke, Meriel Jenney, Jane Pears, Hamish Wallace, Milind Ronghe, Tanzina Chowdhury, Susan Picton, Emma Ross, Lisa Howell, Bernadette Brennan, Gail Halliday, Richard Grundy, Shaun Wilson, Sucheta Vaidya, Daniel Yeomanson, Jessica Bate, Vesna Pavasovic, Jessica Bate, Sabine Irtan, Jesper Brok, Minou Oostveen, Kristina Dzhuma, Mark Weeks, Richard Williams, Mark Powis, Max Pachl, Bruce Okoye, Naima Smeulders, Gordan Vujanic, Oystein Olsen, Tom Watson, Susan Shelmerdine, Dan Saunders, Angela Lopez-Cortes, Taryn Treger, Tom Jackson, Suzanne Tugnait, Lisa Howell, Tanzina Chowdhury, Sam Behjati, Angela Polanco   +56 more
wiley   +1 more source

Changes in Microbiome Activity and Sporadic Viral Infection Help Explain Observed Variability in Microcosm Studies

Frontiers in Microbiology, 2022
The environmental conditions experienced by microbial communities are rarely fully simulated in the laboratory. Researchers use experimental containers (“bottles”), where natural samples can be manipulated and evaluated.
Helena L. Pound, Robbie M. Martin, Brittany N. Zepernick, Courtney J. Christopher, Sara M. Howard, Hector F. Castro, Shawn R. Campagna, Gregory L. Boyer, George S. Bullerjahn, Justin D. Chaffin, Steven W. Wilhelm   +10 more
doaj   +1 more source

Fluorescent small molecule donors [PDF]

Chemical Society Reviews
Recent progress in the molecular design, structural classification, mechanisms of generation, triggered release, structure–activity relationships, and fluorescence response mechanism of fluorescent small molecule donors is discussed.
Guang Chen, Jing Yu, Luling Wu, Xinrui Ji, Jie Xu, Chao Wang, Siyue Ma, Qing Miao, Linlin Wang, Chen Wang, Simon E. Lewis, Yanfeng Yue, Zhe Sun, Yuxia Liu, Bo Tang, Tony D. James   +15 more
openaire   +2 more sources

A Systematic Review of Evidence on the Clinical Effectiveness of Surveillance Imaging in Children With Medulloblastoma and Ependymoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Surveillance imaging aims to detect tumour relapse before symptoms develop, but it's unclear whether earlier detection of relapse leads to better outcomes in children and young people (CYP) with medulloblastoma and ependymoma. This systematic review aims to identify relevant literature to determine the efficacy of surveillance magnetic ...
Lucy Shepherd, Melissa Taylor, Helen Fulbright, Bob Phillips   +3 more
wiley   +1 more source

N-linoleyltyrosine resisted the growth of non-small cell lung cancer cells via the regulation of CB1 and CB2 involvement of PI3K and ERK pathways

Frontiers in Pharmacology, 2023
Background: N-linoleyltyrosine (NITyr), one of the anandamide analogs, exerts activity via the endocannabinoid receptors (CB1 and CB2), which showed anti-tumor effects in various tumors.
Yan Hu, Yan Hu, Zhe Zhao, Zhe Zhao, Yuan-Ting Liu, Ze-Cheng Xu, Jing-Yi Li, Jing-Yi Li, Zheng-Yu Yang, Rui-Wang, Yun-Qi Yang, Jia-Hui Zhang, Si-Yuan Qiu, Tao He, Yi-Ying Wu, Sha Liu, Sha Liu   +16 more
doaj   +1 more source

Small-Molecule-Binding Riboswitches

Microbiology Spectrum, 2018
ABSTRACT RNA is a versatile biomolecule capable of transferring information, taking on distinct three-dimensional shapes, and reacting to ambient conditions. RNA molecules utilize a wide range of mechanisms to control gene expression. An example of such regulation is riboswitches.
Thea S, Lotz, Beatrix, Suess
openaire   +2 more sources