Results 41 to 50 of about 10,015,764 (349)
eLife, 2016 The membrane-bound transcription factor ATF6α plays a cytoprotective role in the unfolded protein response (UPR), required for cells to survive ER stress. Activation of ATF6α promotes cell survival in cancer models. We used cell-based screens to discover
Ciara M Gallagher +11 more
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Small-Molecule-Binding Riboswitches [PDF]
Microbiology Spectrum, 2018 ABSTRACT RNA is a versatile biomolecule capable of transferring information, taking on distinct three-dimensional shapes, and reacting to ambient conditions. RNA molecules utilize a wide range of mechanisms to control gene expression. An example of such regulation is riboswitches.
Beatrix Suess, Thea S. Lotz
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Clinical rel mutations in Staphylococcus aureus prime pathogen expansion under nutrient stress
mSphere, 2023 Persistent infection by Staphylococcus aureus has been linked to the bacterial stringent response (SR), a conserved stress response pathway regulated by the Rel protein.
Edwin Chen +6 more
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Small-Molecule Inhibition of Bacterial Biofilm
ACS Omega, 2020 Antibiotic resistance is a massive and serious threat to human welfare and healthcare. Apart from being genetically resistant to antibiotics, the other important mechanism by which bacteria can evade antibiotics is multidrug tolerance.
Anirban Ghosh +2 more
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Frontiers in Microbiology, 2022 The environmental conditions experienced by microbial communities are rarely fully simulated in the laboratory. Researchers use experimental containers (“bottles”), where natural samples can be manipulated and evaluated.
Helena L. Pound +10 more
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Small molecule cytokine mimetics
Chemistry & Biology, 1999 A number of reports describe small peptides, and even bona fide small organic molecules, that activate homodimeric cytokine receptors and show cytokine-like activity in vitro and in vivo. These cases can be examined in light of the mechanistic and thermodynamic principles that govern cytokine-receptor activation.
Adrian Whitty, Christopher W. Borysenko
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Small molecule approaches in plants [PDF]
Current Opinion in Chemical Biology, 2007 Small molecules offer exciting opportunities for plant science. So far, bioactive small molecules have been identified as plant hormones, herbicides, growth regulators, or taken from animal research. Recently, plant scientists have started to explore further the chemical space for novel modulators of plant hormone signalling, and have followed up this ...
Kaschani, F., Van der Hoorn, R.
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Dendritic cells steering antigen and leukocyte traffic in lymph nodes
FEBS Letters, EarlyView.Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta +3 more
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Journal of Pharmacological Sciences, 2021 Anandamide (AEA) analogs show fair effects in counteracting the deterioration of Alzheimer's disease (AD). Our previous studies demonstrated that AEA analog-N-linoleyltyrosine (NITyr) exerted significant activities.
Chun-mei Long +6 more
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Frontiers in Pharmacology, 2023 Background: N-linoleyltyrosine (NITyr), one of the anandamide analogs, exerts activity via the endocannabinoid receptors (CB1 and CB2), which showed anti-tumor effects in various tumors.
Yan Hu +16 more
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