Results 51 to 60 of about 2,196,436 (350)

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Infrared spectroscopy of small-molecule endofullerenes

, 2013
Hydrogen is one of the few molecules which has been incarcerated in the molecular cage of C$_{60}$ and forms endohedral supramolecular complex H$_2$@C$_{60}$. In this confinement hydrogen acquires new properties.
Bačić, Z., Carravetta, M., Chen, J. Y. -C., Ge, Min, Hüvonen, D., Komatsu, K., Lei, Xuegong, Levitt, M. H., Mamone, S., Murata, Y., Nagel, U., Peedu, L., Rõõm, T., Turro, N. J., Xu, Minzhong, Ye, Shufeng   +15 more
core   +3 more sources

Genetically Encoded Photo-cross-linkers Map the Binding Site of an Allosteric Drug on a G Protein-Coupled Receptor [PDF]

, 2012
G protein-coupled receptors (GPCRs) are dynamic membrane proteins that bind extracellular molecules to transduce signals. Although GPCRs represent the largest class of therapeutic targets, only a small percentage of their ligand-binding sites are ...
Abrol, Ravinder, Goddard, William A., III, Grunbeck, Amy, Huber, Thomas, Sakmar, Thomas P., Trzaskowski, Bartosz   +5 more
core   +1 more source

Small-Molecule Kinase Downregulators [PDF]

Cell Chemical Biology, 2018
New opportunities to advance small-molecule kinase ligands that downregulate their cognate target binding proteins are discussed. Rationally designed heterobifunctional kinase degraders are compared with ATP site ligands that were serendipitously found to cause kinase downregulation.
openaire   +2 more sources

Selenium-containing small molecules

Communications Chemistry, 2022
The role of selenium in proteins and nucleic acids is well-established, but the pathway for incorporating selenium into small molecules remains unknown. Now, using bioinformatics tools, a selenium-incorporating gene cluster is discovered from immense genomic data, leading to the identification of selenoneine from microorganisms and the elucidation of a
openaire   +3 more sources

Clinical Characteristics and Prognostic Risk Factors for Pediatric B‐Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐cell lymphoblastic lymphoma (B‐LBL) represents a rare variety of non‐Hodgkin lymphoma, with limited research on its biology, progression, and management. Methods A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)‐
Zhijuan Liu, Jian Wang, Ling Jin, Yanlong Duan, Fu Li, Yueping Jia, Leping Zhang, Xiaojun Yuan, Wei Liu, Ying Liu, Ansheng Liu, Mincui Zheng, Yunpeng Dai, Lian Jiang, Lirong Sun, Xiaowen Zhai, Rong Liu, Chunju Zhou, Zifen Gao, Yonghong Zhang, Xiaomei Yang   +20 more
wiley   +1 more source

Characterization of carbapenem-resistant Acinetobacter baumannii isolates in a Chinese teaching hospital

Frontiers in Microbiology, 2015
Carbapenem-resistant Acinetobacter baumannii (CRAB) presents a serious therapeutic and infection control challenge. In this study, we investigated the epidemiological and molecular differences of CRAB, and the threatening factors for contributing to ...
Yaowen eChang, Guangxin eLuan, Ying eXu, Yanhong eWang, Min eShen, Chi eZhang, Wei eZheng, Jinwei eHuang, Jingni eYang, Xu eJia, Baodong eLing   +10 more
doaj   +1 more source

DELP Treatment on Vision and Retinal Microcirculation in Patients With Acute Ischemic Stroke: Report of Five Cases and Literature Review

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background The delipid extracorporeal lipoprotein filter from plasma (DELP) treatment can effectively reduce blood lipid, increase blood flow, and improve neurological deficits in patients with acute ischemic stroke (AIS). However, its effect on vision and retinal microcirculation in stroke patients has never been reported.
Ning Li, Ronghua Hong, Hua You, Feiping Xu, Qingjun Zhang, Yiwen Lin, Yuting Su, Danmei Lan, Lingjing Jin, Junhui She   +9 more
wiley   +1 more source

Synthesis of 2-trifluoromethylpyrazolo[5,1-a]isoquinolines via silver triflate-catalyzed or electrophile-mediated one-pot tandem reaction

Beilstein Journal of Organic Chemistry, 2014
An efficient one-pot tandem cyclization/[3 + 2] cycloaddition reaction of N’-(2-alkynylbenzylidene)hydrazides with ethyl 4,4,4-trifluorobut-2-ynoate under silver triflate-catalyzed or electrophile-mediated conditions is described.
Xiaoli Zhou, Meiling Liu, Puying Luo, Yingjun Lai, Tangtao Yang, Qiuping Ding   +5 more
doaj   +1 more source

Transitions Induced by the Discreteness of Molecules in a Small Autocatalytic System

, 2001
Autocatalytic reaction system with a small number of molecules is studied numerically by stochastic particle simulations. A novel state due to fluctuation and discreteness in molecular numbers is found, characterized as extinction of molecule species ...
B. Alberts, B. Hess, B. Hess, C. Furusawa, C. Furusawa, D. A. Kessler, F. Rieke, G. Nicolis, H. H. McAdams, K. Kaneko, K. Kaneko, K. Matsumoto, K. Wiesenfeld, Kunihiko Kaneko, M. Delbruck, M. Eigen, N. G. van Kampen, P. Stange, P. Stange, P. Stange, W. Horsthemke, Yuichi Togashi   +21 more
core   +1 more source