Results 71 to 80 of about 10,015,764 (349)
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Fluorescent small molecule donors [PDF]
Chemical Society ReviewsRecent progress in the molecular design, structural classification, mechanisms of generation, triggered release, structure–activity relationships, and fluorescence response mechanism of fluorescent small molecule donors is discussed.
Guang Chen +15 more
openaire +2 more sources
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
BMC Infectious Diseases, 2021 Background Chlorhexidine is a widely used disinfectant in clinical settings and a broad-spectrum antimicrobial agent effective against aerobic and anaerobic bacteria.
Fei Lin +4 more
doaj +1 more source
Angewandte ChemieAbstractRNA is a central molecule in life, involved in a plethora of biological processes and playing a key role in many diseases. Targeting RNA emerges as a significant endeavor in drug discovery, diverging from conventional protein‐centric approaches to tackle various pathologies.
Javier Bonet‐Aleta +3 more
openaire +5 more sources
Selenium-containing small molecules
Communications Chemistry, 2022 The role of selenium in proteins and nucleic acids is well-established, but the pathway for incorporating selenium into small molecules remains unknown. Now, using bioinformatics tools, a selenium-incorporating gene cluster is discovered from immense genomic data, leading to the identification of selenoneine from microorganisms and the elucidation of a
openaire +3 more sources
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Science Advances, 2018 A supramolecular polymer with integrated properties is readily obtained from a natural small molecule. Polymeric materials with integrated functionalities are required to match their ever-expanding practical applications, but there is always a trade-off ...
Qi Zhang +5 more
semanticscholar +1 more source
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
FEBS Letters, EarlyView.miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan +10 more
wiley +1 more source