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Cell-based high-content screening of small-molecule libraries
Current Opinion in Chemical Biology, 2007Advanced microscopy and the corresponding image analysis have been developed in recent years into a powerful tool for studying molecular and morphological events in cells and tissues. Cell-based high-content screening (HCS) is an upcoming methodology for the investigation of cellular processes and their alteration by multiple chemical or genetic ...
Korn, K., Krausz, E.
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Orthogonality of SFC versus HPLC for Small Molecule Library Separation
Journal of Combinatorial Chemistry, 2010Preparative HPLC and HPLC-MS are well established as the methods of choice for purification of pharmaceutical library compounds. Recent advances in supercritical fluid chromatography (SFC) have now made SFC a viable alternative to HPLC for this application. One of the potential arguments for using SFC in place of, or in addition to, HPLC is that it may
Harold N, Weller +10 more
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Design, synthesis and selection of DNA-encoded small-molecule libraries
Nature Chemical Biology, 2009Biochemical combinatorial techniques such as phage display, RNA display and oligonucleotide aptamers have proven to be reliable methods for generation of ligands to protein targets. Adapting these techniques to small synthetic molecules has been a long-sought goal.
Matthew A, Clark +39 more
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Diversity Oriented Synthesis of Small Molecule Libraries
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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Tagged Small Molecule Library Approach for Facilitated Chemical Genetics
Accounts of Chemical Research, 2007Chemical genetics is a powerful method which utilizes small molecule regulators to reveal the molecular basis of diverse biological processes. However, the current chemical genetic approach sometimes meets a serious bottleneck during the process of target identification.
Ahn, Young-Hoon, Chang, Young-Tae
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Journal of Combinatorial Chemistry, 2008
In "one-bead-one-compound" (OBOC) combinatorial chemistry, a compound-bead library with hundreds of thousands to millions of diversities can be rapidly generated such that each bead displays only one chemical entity. The highly efficient "libraries-from-libraries" approach involves the global transformation of a peptide library into many small molecule
Joseph C, Kappel, Yi C, Fan, Kit S, Lam
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In "one-bead-one-compound" (OBOC) combinatorial chemistry, a compound-bead library with hundreds of thousands to millions of diversities can be rapidly generated such that each bead displays only one chemical entity. The highly efficient "libraries-from-libraries" approach involves the global transformation of a peptide library into many small molecule
Joseph C, Kappel, Yi C, Fan, Kit S, Lam
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Large-Scale Annotation of Small-Molecule Libraries Using Public Databases
Journal of Chemical Information and Modeling, 2007While many large publicly accessible databases provide excellent annotation for biological macromolecules, the same is not true for small chemical compounds. Commercial data sources also fail to encompass an annotation interface for large numbers of compounds and tend to be cost prohibitive to be widely available to biomedical researchers.
Yingyao Zhou +6 more
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Developing small-molecule libraries for drug discovery
Trends in Biotechnology, 1996D J, Gravert, K D, Janda
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