Results 111 to 120 of about 1,523,383 (315)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP
, 2013 Through controlling the nuclear level of active positive transcription elongation factor b (P-TEFb), the 7SK small nuclear RNA (snRNA) functions as a key regulator of RNA polymerase II transcription.
Kiss, T. +4 more
core +1 more source
Princeton-LSI-ResearchComputing/PE-small-RNA-seq-analysis: v1.1.0
, 2023 <p>SmallRNA-Seq analysis for publication</p> <p>Initial workflow by @troycomi Small RNA Annotation script by <a href="https://scholar.google.com/citations?user=QU0hXeIAAAAJ&hl=en&oi=sra">Jun Yan</a></p ...
Lance Parsons, Troy Comi
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
, 2015 B2 RNA is a mouse non-coding RNA that binds directly to RNA polymerase II (Pol II) and represses transcription by disrupting critical interactions between the polymerase and promoter DNA.
Jennifer Kugel +2 more
core +1 more source
Ahead and behind: a small, small RNA world [PDF]
RNA, 2015 A normally referenced version of this note is available: mcdb.colorado.edu/labs/yarus/index.html Article and publication date are at http://www.rnajournal.org/cgi/doi/10.1261/rna.051086.115. Freely available online through the RNA Open Access option.
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Demystifying Small RNA Pathways [PDF]
Developmental Cell, 2006 The Keystone Symposium entitled “RNAi and Related Pathways,” organized by Craig Mello (University of Massachusetts), Phillip Zamore (University of Massachusetts) and James Carrington (Oregon State University), was held in Vancouver, British Columbia. The meeting participants reviewed recent reports and presented new advances in our understanding of the
openaire +2 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source