Results 141 to 150 of about 595,059 (301)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Small-Signal Stability Analysis of Wind Power System Based on DFIG
, 2013 This paper focuses on the small-signal stability of power system integrated with DFIG-based wind farm. The model of DFIG for small-signal stability analysis has built; the 3-generator 9-bus WECC test system is modified to investigate the impacts of large
Kai Liao, Bin Sun, Zhengyou He, Yong Jia
core
Feature Selection for Small-Signal Stability Assessment [PDF]
, 2002 This paper introduces different feature selection techniques for neural network based small-signal stability assessment. Large-scale power systems like the European interconnected network may experience low frequency oscillations between remote parts of the system. These oscillations are caused by large power transits in the network.
openaire +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Small-signal stability assessment of active distribution networks with dynamic loads
, 2012 This paper investigates small-signal stability of a distribution system with distributed generator and induction motor load, as a dynamic element. The analysis is carried out over a distribution test system with different types of induction motor loads ...
T Orchi (13704934) +2 more
core
Small-Signal Stability Analysis and Voltage Control Parameter Design for DC Microgrids
Small-signal instability issues will occur in the DC microgrid when the high-frequency oscillation peaks of the voltage closed-loop transfer function are not effectively suppressed.
Jiakun An +5 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source