Results 121 to 130 of about 595,059 (301)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Genetic Algorithms in Power System Small Signal Stability Analysis
, 2007 Power system small signal stability analysis aims to explore different small signal stability conditions and controls, namely, 1) exploring the power system security domains and boundaries in the space of power system parameters of interest, including ...
Dong Yuri +3 more
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Small Signal Stability Analysis of Kurdistan Regional Power System
CoRR, 2012 Abstract: This paper presents for the first time a mathematical model for evaluating the Planned Kurdistan RegionalPower System (KRPS) for its ability to maintain stability under small disturbances and fluctuations duringnormal operating conditions.
openaire +3 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Power System Small Signal Stability Analysis Using Genetic Optimization Techniques
, 2007 Power system small signal stability analysis aims to explore different small signal stability conditions and controls, namely, 1) exploring the power system security domains and boundaries in the space of power system parameters of interest, including ...
Yuri V. Makarov +2 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Small Signal Stability of an Unregulated Power System
, 2002 Rotor angle stability is the ability of the interconnected synchronous machines of a power system to remain in synchronism. This stability problem is concerned with the behavior of one or more synchronous machine after they have been perturbed.
singhvi, vikas
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Stability analysis of a TWT against the reflected signals using alarge-signal model. [PDF]
, 2000 A large signal model is used to analyze the stability of a high gain helix TWT against the reflected signals caused by mismatches at its input and output terminations.
Carter, Richard G. +2 more
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