Results 71 to 80 of about 559,527 (265)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Small-Signal stability analysis of MMC-HVDC system with saturated transformer

International Journal of Electrical Power & Energy Systems
Transformer saturation has a significant impact on the stability of HVDC systems. While traditional research has primarily focused on LCC-HVDC systems, studies on MMC systems remain limited. Given the anticipated dominance of MMC technology in the future,
Hanwen Wang, Yang Wang, Xianyong Xiao, Yunzhu Chen, Shupeng Li, Zhijun Er, Zhenbin Li   +6 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Delay‐dependent small‐signal stability analysis of inverter‐based islanded microgrids

IET Smart Grid
The stability of an inverter‐based hierarchical microgrid is challenged by inverter controls, network dynamics, load models and communication delays among the interacting agents.
Chaudhry Talha Hassan, Tariq Mahmood Jadoon, Anmar Arif   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Dynamic impact of hybrid wind-solar photovoltaic power injection on small signal stability of Nigerian 11kV power system using Self Organizing Map neural network

Scientific African
Power industry reorganization, legislation on greenhouse gas emissions and inadequate conventional generation capacity encourage the idea of incorporating Distributed Generation (DG) into the distribution networks as unconventional sources of power ...
ADEBIMPE Abiodun Michael, OLULOPE Paul Kehinde, OLAJIGA Benson Olawale, OLAJUYIN Elijah Adebayo, ADEOYE Oluwatosin Samuel   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Coupling Influence on the dq Impedance Stability Analysis for the Three-Phase Grid-Connected Inverter

Energies, 2019
The dq impedance stability analysis for a grid-connected current-control inverter is based on the impedance ratio matrix. However, the coupled matrix brings difficulties in deriving its eigenvalues for the analysis based on the general Nyquist criterion.
Chuanyue Li, Taoufik Qoria, Frederic Colas, Jun Liang, Wenlong Ming, Francois Gruson, Xavier Guillaud   +6 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source