Results 131 to 140 of about 6,330,702 (296)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Dim Small Target Detection and Tracking: A Novel Method Based on Temporal Energy Selective Scaling and Trajectory Association

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Effective detection and tracking of dim and small targets with low SCR has become a research hotspot due to its wide range of applications. However, most of the previously proposed methods seldom utilize the abundant temporal features formed by target ...
Weihua Gao, Wenlong Niu, Wenlong Lu, Pengcheng Wang, Zhaoyuan Qi, Xiaodong Peng, Zhen Yang   +6 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

CSD-YOLOv8s: Dense Sheep Small Target Detection Model Based on UAV Images

智慧农业
ObjectiveThe monitoring of livestock grazing in natural pastures is a key aspect of the transformation and upgrading of large-scale breeding farms. In order to meet the demand for large-scale farms to achieve accurate real-time detection of a large ...
WENG Zhi, LIU Haixin, ZHENG Zhiqiang
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Small target detection based on modified local reverse entropy operator

Tongxin xuebao, 2013
A small-target detection approach was proposed,which is based on the modified local reverse entropy operator and the improved region growing technology.The approa adopted the fact that the emergence of small target could lead to the large change of local
He DENG, Yan-tao WEI, Ming-wen TONG, Shao-cheng QU   +3 more
doaj  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

IFD-YOLO: A Lightweight Infrared Sensor-Based Detector for Small UAV Targets

Sensors
The detection of small targets in infrared imagery captured by unmanned aerial vehicles (UAVs) is critical for surveillance and monitoring applications. However, this task is challenged by the small target size, low signal-to-noise ratio, and the limited
Fu Li, Xuehan Lv, Ming Zhao, Wangyu Wu
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source