Results 11 to 20 of about 2,530,483 (266)
Contextualized Small Target Detection Network for Small Target Goat Face Detection
Animals, 2023 With the advancement of deep learning technology, the importance of utilizing deep learning for livestock management is becoming increasingly evident. goat face detection provides a foundation for goat recognition and management.
Yaxin Wang +4 more
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Small Molecules Targeting Viral RNA
International Journal of Molecular Sciences, 2023 The majority of antivirals available target viral proteins; however, RNA is emerging as a new and promising antiviral target due to the presence of highly structured RNA in viral genomes fundamental for their replication cycle. Here, we discuss methods for the identification of RNA-targeting compounds, starting from the determination of RNA structures ...
Gregory Mathez, Valeria Cagno
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Small molecules targeting viral
WIREs RNA, 2016 Highly conserved noncoding RNA (ncRNA) elements in viral genomes and transcripts offer new opportunities to expand the repertoire of drug targets for the development of antiinfective therapy. Ligands binding to ncRNA architectures are able to affect interactions, structural stability or conformational changes and thereby block processes essential for ...
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Small molecule inhibitors targeting the cancers
MedComm, 2022 AbstractCompared with traditional therapies, targeted therapy has merits in selectivity, efficacy, and tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer. Due to their advantages in a wide range of targets, convenient medication, and the ability to penetrate into the central nervous system, many efforts have ...
Gui‐Hong Liu +4 more
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Small‐Molecule Modulators for Epigenetics Targets
ChemMedChem, 2013 A capital conference: Influencing epigenetic mechanisms may be highly relevant for future therapies of various diseases such as cancer, inflammation, and metabolic disorders. Leading experts in the field gathered in Berlin on June 5-6, 2013 at a Bayer HealthCare Life Science Workshop to share recent success stories and to discuss future trends.
Knapp, S, Weinmann, H
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Targeting PTEN using small molecule inhibitors [PDF]
Methods, 2015 PTEN (phosphatase and tensin homologue deleted on chromosome 10) is well known as a tumour suppressor. It's PI(3,4,5)P3 lipid phosphatase activity is an important counteracting mechanism in PI 3-kinase (phosphoinositide 3-kinase) signalling. Furthermore, PTEN lies upstream of Akt kinase, a key enzyme in insulin signalling regulating glucose uptake and ...
Mak, LH, Woscholski, R
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Small-Molecule Targets in Tumor Immunotherapy [PDF]
Natural Products and Bioprospecting, 2018 Cancer immunotherapy has been widely recognized as a powerful approach to fight cancers. To date, over 50 phase III trials in cancer immunotherapy are in progress. Among the many immunotherapy approaches, immune checkpoint therapy has attracted considerable attention.
Hui-Fang Zhu, Yan Li
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Small-Molecule Targets in Immuno-Oncology [PDF]
Cell Chemical Biology, 2017 Advances in understanding the role and molecular mechanisms underlying immune surveillance and control of (pre)malignancies is revolutionizing clinical practice in the treatment of cancer. Presently, multiple biologic drugs targeting the immune checkpoint proteins PD(L)1 or CTLA4 have been approved and/or are in advanced stages of clinical development ...
Dashyant, Dhanak +3 more
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Agronomy, 2023 Weather disturbances, difficult backgrounds, the shading of fruit and foliage, and other elements can significantly affect automated yield estimation and picking in small target apple orchards in natural settings.
Li Ma +4 more
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Frontiers in Plant ScienceThe aim of this study is to propose a lightweight YOLOv8n maize seedling detection algorithm that incorporates multi-scale features to address the problems of large number of model parameters and computation, low real-time performance, and small ...
Pengbo Feng +4 more
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