Results 11 to 20 of about 6,330,702 (296)

Targeting RNA structures with small molecules

Nature Reviews Drug Discovery, 2022
RNA adopts 3D structures that confer varied functional roles in human biology and dysfunction in disease. Approaches to therapeutically target RNA structures with small molecules are being actively pursued, aided by key advances in the field including the development of computational tools that predict evolutionarily conserved RNA structures, as well ...
Jessica L. Childs-Disney, Xueyi Yang, Quentin M. R. Gibaut, Yuquan Tong, Robert T. Batey, Matthew D. Disney   +5 more
openaire   +4 more sources

Contextualized Small Target Detection Network for Small Target Goat Face Detection

Animals, 2023
With the advancement of deep learning technology, the importance of utilizing deep learning for livestock management is becoming increasingly evident. goat face detection provides a foundation for goat recognition and management. In this study, we proposed a novel neural network specifically designed for goat face object detection, addressing ...
Yaxin Wang, Ding Han, Liang Wang, Ying Guo, Hongwei Du   +4 more
openaire   +3 more sources

Small Molecules Targeting Viral RNA

International Journal of Molecular Sciences, 2023
The majority of antivirals available target viral proteins; however, RNA is emerging as a new and promising antiviral target due to the presence of highly structured RNA in viral genomes fundamental for their replication cycle. Here, we discuss methods for the identification of RNA-targeting compounds, starting from the determination of RNA structures ...
Gregory Mathez, Valeria Cagno
openaire   +3 more sources

Focusing and orienting spatial attention differently modulate crowding in central and peripheral vision [PDF]

, 2018
The allocation of attentional resources to a particular location or object in space involves two distinct processes: an orienting process and a focusing process.
Albonico, Andrea, Bricolo, Emanuela, Daini, Roberta, Frasson, Eleonora, Martelli, Marialuisa   +4 more
core   +1 more source

A Small Target Neutrino Deep-Inelastic Scattering Experiment at the First Muon Collider [PDF]

, 1998
Several different scenarios for neutrino scattering experiments using a neutrino beam from the muon collider complex are discussed. The physics reach of a neutrino experiment at the front end of a muon collider is shown to extend far beyond that of ...
Harris, Deborah A., McFarland, Kevin S.
core   +3 more sources

Modelling aggregation on the large scale and regularity on the small scale in spatial point pattern datasets [PDF]

, 2015
We consider a dependent thinning of a regular point process with the aim of obtaining aggregation on the large scale and regularity on the small scale in the resulting target point process of retained points.
Baddeley, Berthelsen, Biscio, Chiu, Cox, Cressie, Daley, Diggle, Frédéric Lavancier, Getis, Goldstein, Goreaud, Illian, Jesper Møller, Kautz, Kendall, Kingman, Lantuéjoul, Lavancier, Lavancier, Lieshout, Macchi, Matérn, McCullagh, Molchanov, Murray, Møller, Møller, Møller, Møller, Møller, Møller, Pélissier, R Core Team, Rue, Ruelle, Schlather, Stoyan   +37 more
core   +4 more sources

Small molecules targeting viral RNA [PDF]

WIREs RNA, 2016
Highly conserved noncoding RNA (ncRNA) elements in viral genomes and transcripts offer new opportunities to expand the repertoire of drug targets for the development of antiinfective therapy. Ligands binding to ncRNA architectures are able to affect interactions, structural stability or conformational changes and thereby block processes essential for ...
openaire   +4 more sources

Small molecule inhibitors targeting the cancers

MedComm, 2022
AbstractCompared with traditional therapies, targeted therapy has merits in selectivity, efficacy, and tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer. Due to their advantages in a wide range of targets, convenient medication, and the ability to penetrate into the central nervous system, many efforts have ...
Gui‐Hong Liu, Tao Chen, Xin Zhang, Xue‐Lei Ma, Hua‐Shan Shi   +4 more
openaire   +3 more sources

Small‐Molecule Modulators for Epigenetics Targets

ChemMedChem, 2013
A capital conference: Influencing epigenetic mechanisms may be highly relevant for future therapies of various diseases such as cancer, inflammation, and metabolic disorders. Leading experts in the field gathered in Berlin on June 5-6, 2013 at a Bayer HealthCare Life Science Workshop to share recent success stories and to discuss future trends.
Knapp, S, Weinmann, H
openaire   +3 more sources

Targeting PTEN using small molecule inhibitors [PDF]

Methods, 2015
PTEN (phosphatase and tensin homologue deleted on chromosome 10) is well known as a tumour suppressor. It's PI(3,4,5)P3 lipid phosphatase activity is an important counteracting mechanism in PI 3-kinase (phosphoinositide 3-kinase) signalling. Furthermore, PTEN lies upstream of Akt kinase, a key enzyme in insulin signalling regulating glucose uptake and ...
Mak, LH, Woscholski, R
openaire   +4 more sources