Results 21 to 30 of about 2,560,191 (266)
Trapping Moving Targets with Small Molecules [PDF]
Science, 2009 Structure-based drug design traditionally uses static protein models as inspirations for focusing on “active” site targets. Allosteric regulation of biological macromolecules, however, is affected by both conformational and dynamic properties of the protein or protein complex and can potentially lead to more avenues for therapeutic development.
Gregory M, Lee, Charles S, Craik
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Applied SciencesImage detection technology is of paramount importance across various fields. This significance is not only seen in general images with everyday scenes but also holds substantial research value in the field of remote sensing. Remote sensing images involve
Qiang Fu +3 more
doaj +1 more source
Semantic Segmentation Algorithm of Rice Small Target Based on Deep Learning
Agriculture, 2022 At present, rice is generally in a state of dense adhesion and small granular volume during processing, resulting in no effective semantic segmentation method for rice to extract complete rice.
Shuofeng Li +4 more
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Targeting Twist expression with small molecules [PDF]
MedChemComm, 2017 Twist, as one of the important embryonic transcription factors, regulates epithelial–mesenchymal transition (EMT) and migration in embryo formation and cancer development.
Haixiang Pei +3 more
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High-Resolution Drone Detection Based on Background Difference and SAG-YOLOv5s
Sensors, 2022 To solve the problem of low accuracy and slow speed of drone detection in high-resolution images with fixed cameras, we propose a detection method combining background difference and lightweight network SAG-YOLOv5s.
Yaowen Lv +5 more
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IEEE AccessAccurate detection of pest species in cotton fields is vital for effective agricultural management and the development of pest-resistant crops. However, achieving high-throughput and precise pest detection in cotton fields remains a challenging task ...
Chenglei Sun +4 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Neuroblastoma is the most common extracranial solid tumor in early childhood. Its clinical behavior is highly variable, ranging from spontaneous regression to fatal outcome despite intensive treatment. The International Society of Pediatric Oncology Europe Neuroblastoma Group (SIOPEN) Radiology and Nuclear Medicine Specialty Committees ...
Annemieke Littooij +11 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Adolescent siblings of children with cancer are at elevated risk for psychosocial problems. Unfortunately, various barriers such as limited family time and resources, conflicting schedules, and psychosocial staffing constraints at cancer centers hinder sibling access to support.
Christina M. Amaro +10 more
wiley +1 more source
Sensors, 2014 This paper presents a region-adaptive clutter rejection method for small target detection in sea-based infrared search and track. In the real world, clutter normally generates many false detections that impede the deployment of such detection systems ...
Sungho Kim, Joohyoung Lee
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman +17 more
wiley +1 more source