Results 191 to 200 of about 1,168,068 (349)

Multi-center evaluation of an automated pipeline to segment perivascular spaces from routine MRI in patients with small vessel disease

Alberto De Luca, Ana Sofia Costa, Geert Jan Biessels, Roberto Duarte Coello, María del C. Valdés Hernández, Lucia Ballerini, Francesca M. Chappell, Rosalind Brown, José Bernal Moyano, Wiesje M. van der Flier, Argonde C. van Harten, Frederik Barkhof, Joanna M. Wardlaw   +12 more
openalex   +1 more source

Age-related cerebral small vessel disease and inflammaging [PDF]

, 2020
Tiemei Li, Yinong Huang, Wei Cai, Xiaodong Chen, Xuejiao Men, Tingting Lü, Aiming Wu, Zhengqi Lu   +7 more
openalex   +1 more source

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Design of Trials for Cerebral Small Vessel Disease and Vascular Cognitive Impairment. [PDF]

Neurol Int
Phan E, Loo SP, Quinn TJ.
europepmc   +1 more source

Retinal small vessel pathology is associated with disease burden in multiple sclerosis [PDF]

Rebecca Wicklein, Linus Kreitner, Anna Wild, Lilian Aly, Daniel Rueckert, Bernhard Hemmer, Thomas Korn, Martin J. Menten, Benjamin Knier   +8 more
openalex   +1 more source

Human Brain Vasculature‐on‐a‐Chip Model Constructed With Microvessels Isolated From Cryopreserved Postmortem Human Brain Tissue

Advanced Healthcare Materials, EarlyView.
This manuscript describes the cultivation of viable microvessels from cryopreserved human brain tissue. When embedded in hydrogels and cultured in microfluidic devices, these microvessels exhibit complex architectures reminiscent of arterioles and capillaries, can be perfused, and display intact barrier function. Collectively, these results demonstrate
Brian J. O'Grady, A. Scott McCall, Samuel Cullison, Daniel Chavarria, Matthew S. Schrag, Ethan S. Lippmann   +5 more
wiley   +1 more source

An iPSC-derived model for drug screening in cerebral small vessel disease. [PDF]

J Cereb Blood Flow Metab
Granata A, Al-Thani M, Goodwin-Trotman M, Smith DM, Van Agtmael T, Markus HS.   +5 more
europepmc   +1 more source

Characterization of an Injectable Poly(vinyl alcohol)‐gelatin Hydrogel for Growth Factor Delivery in an Orthopedic Application

Advanced Healthcare Materials, EarlyView.
This work introduces photo‐crosslinkable tyraminated poly(vinyl alcohol)‐gelatin (PVA‐GT) hydrogels as tunable injectable platforms for tissue engineering and growth factor delivery applications. This schematic illustrates the two developed hydrogel formulations and the experimental workflow used to evaluate their physico‐chemical properties in vitro ...
Alessia Longoni, Gretel S. Major, Sam Arnold, Samuel Tomkins, Eugenia Spessot, Scott Loeffler, Kieran Lau, Richard Tan, Jessica Harte, Roslyn Kemp, Tess Reynolds, Jelena Rnjak‐Kovacina, Gary J. Hooper, Tim B. F. Woodfield, David C. Kieser, Khoon S. Lim   +15 more
wiley   +1 more source

Cerebral Small Vessel Disease Burden in Acute Ischemic Stroke and the Role of Physical Activity: Cross-Sectional Study. [PDF]

Brain Behav
Damsbo AG, Blauenfeldt RA, Vestergaard SB, Pedersen NL, Ørskov KM, Hindsholm MF, Bilgin-Freiert A, Simonsen CZ, Johnsen SP, Dalby RB, Andersen G, Mortensen JK.   +11 more
europepmc   +1 more source

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

Advanced Healthcare Materials, EarlyView.
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins, Samuel L. Hallam, Mariah J. Austin, Adrianne M. Rosales   +3 more
wiley   +1 more source