Results 171 to 180 of about 10,358,075 (261)

High‐Density E. Coli Cultivation Arrays for Combinatorial Drug Testing With Subsequent Lipid Profiling by MALDI‐MS

Advanced Science, EarlyView.
High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld, C. L. Dietsche, F‐L. Born, I. Onipko, L. Blaase, P. S. Dittrich   +5 more
wiley   +1 more source

The association between obstructive sleep apnea and total cerebral small vessel disease burden-Neurovascular insights of OSA. [PDF]

Front Neurosci
Zhao R, Cui G, Zhang X, Bai Y, Peng Z, Zhao H, Wang R, Ma W, Lv D.   +8 more
europepmc   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

Neurovascular effects of tadalafil in patients with cerebral small vessel disease: ETLAS-2 substudy. [PDF]

Brain Commun
Ölmestig J, Mortensen KN, Fagerlund B, Naveed N, Nordling MM, Christensen H, Iversen HK, Poulsen MB, Siebner HR, Kruuse C.   +9 more
europepmc   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Association of Left Ventricular Function With Cerebral Small Vessel Disease and Cognition. [PDF]

J Am Heart Assoc
Huang J, Jali V, Robert C, Chen C, Gong L, Tan ESJ, Richards AM, Ling LH, Hilal S.   +8 more
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Impact of neurovascular coupling and glymphatic function on cognitive function in asymptomatic cerebral small vessel disease. [PDF]

Front Neurol
Chen J, Wang Y, Chen X, Chen C, Shi W, Ding J.   +5 more
europepmc   +1 more source

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

Advanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger, Matthew R. DeWitt, Carly M. Van Wagoner, Claire A. Conarroe, Charles C. Funk, Aaron B. Streit, AeRyon Kim, Richard J. Price, Timothy N. J. Bullock   +8 more
wiley   +1 more source

Association of Enlarged Perivascular Spaces and Total Small Vessel Disease Burden With Kidney Function. [PDF]

Neurology
Nash PS, Ambler G, Best JG, Wilson D, Du H, Al-Shahi Salman R, Jäger HR, Lip GYH, Goeldlin MB, Beyeler M, Bücke P, El-Koussy M, Mattle HP, Panos L, van Dam-Nolen DHK, Dubost F, Hendrikse J, Kooi ME, Mess WH, Nederkoorn PJ, Christ N, Bellut M, Gunkel S, Karayiannis CC, Ly J, Singhal S, Slater LA, Kim YD, Lee KJ, Lim JS, Hara H, Nishihara M, Tanaka J, Yoshikawa M, Demirelli DS, Tanriverdi Z, Uysal E, Coutts SB, Chappell FM, Makin SD, Fung Mak HK, Teo KC, Wong DYK, Hert L, Kubacka M, Lyrer PA, Polymeris AA, Wagner B, Zietz A, Abrigo J, Cheng C, Chu WC, Leung TW, Seiffge DJ, Fischer U, Jung S, Bos D, Fluri F, Phan TG, Srikanth VK, Heo JH, Bae HJ, Yakushiji Y, Orken DN, Smith EE, Wardlaw JM, Kai Lau GK, Engelter ST, Peters N, Soo YOY, Song TJ, Simister RJ, Wheeler DC, Werring DJ.   +73 more
europepmc   +1 more source