Results 191 to 200 of about 10,902,324 (285)

Gait performance in cerebral small vessel disease: associations with cognitive and oculomotor function and exploratory mediation analyses. [PDF]

Front Aging Neurosci
Shen CX, Zhao XY, Wang SY, Miao YW, Liang ZH, Liu L, Zhang BW.   +6 more
europepmc   +1 more source

An RNA‐Binding Protein RBMS1 Promotes Endothelial Cell Autophagy to Maintain Vascular Homeostasis and Suppress Deep Vein Thrombosis

Advanced Science, EarlyView.
RBMS1, an RNA‐binding protein, restores vascular endothelial homeostasis by enhancing ATG3‐mediated autophagy, thereby attenuating thrombus formation and suggesting a potential avenue for further therapeutic exploration in DVT. ABSTRACT Deep vein thrombosis (DVT) is a prevalent vascular disorder characterized by aberrant coagulation within the deep ...
Chu Chu, Xinkui Liu, Nannan Fan, Xiaoyan Yu, Qiaoqiao Han, Yunhong Zhang, Wei Li, Yongqing Cai, Miaomiao Zhou, Fang Li, Feifei Shi, Zhen Zhang, Bin Wang, Xia Li   +13 more
wiley   +1 more source

Association of Enlarged Perivascular Spaces and Total Small Vessel Disease Burden With Kidney Function. [PDF]

Neurology
Nash PS, Ambler G, Best JG, Wilson D, Du H, Al-Shahi Salman R, Jäger HR, Lip GYH, Goeldlin MB, Beyeler M, Bücke P, El-Koussy M, Mattle HP, Panos L, van Dam-Nolen DHK, Dubost F, Hendrikse J, Kooi ME, Mess WH, Nederkoorn PJ, Christ N, Bellut M, Gunkel S, Karayiannis CC, Ly J, Singhal S, Slater LA, Kim YD, Lee KJ, Lim JS, Hara H, Nishihara M, Tanaka J, Yoshikawa M, Demirelli DS, Tanriverdi Z, Uysal E, Coutts SB, Chappell FM, Makin SD, Fung Mak HK, Teo KC, Wong DYK, Hert L, Kubacka M, Lyrer PA, Polymeris AA, Wagner B, Zietz A, Abrigo J, Cheng C, Chu WC, Leung TW, Seiffge DJ, Fischer U, Jung S, Bos D, Fluri F, Phan TG, Srikanth VK, Heo JH, Bae HJ, Yakushiji Y, Orken DN, Smith EE, Wardlaw JM, Kai Lau GK, Engelter ST, Peters N, Soo YOY, Song TJ, Simister RJ, Wheeler DC, Werring DJ.   +73 more
europepmc   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Impact of neurovascular coupling and glymphatic function on cognitive function in asymptomatic cerebral small vessel disease. [PDF]

Front Neurol
Chen J, Wang Y, Chen X, Chen C, Shi W, Ding J.   +5 more
europepmc   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Hypertensive Disorders of Pregnancy Associated With Cerebral Small Vessel Disease Decades Later. [PDF]

J Am Heart Assoc
Baradaran H, Culleton S, Theilen L, Varner MW, Guinto E, Schliep KC.   +5 more
europepmc   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

Two distinct patterns of progression of sporadic cerebral small vessel disease. [PDF]

Int J Stroke
Chen Y, Hong H, Tozer D, Sun Z, Cai L, Li H, Tuladhar AM, De Leeuw FE, Markus HS.   +8 more
europepmc   +1 more source