Results 71 to 80 of about 1,168,068 (349)

Small vessel disease burden and functional brain connectivity in mild cognitive impairment

Cerebral Circulation - Cognition and Behavior
Background: The role of small vessel disease in the development of dementia is not yet completely understood. Functional brain connectivity has been shown to differ between individuals with and without cerebral small vessel disease.
Sofia Marcolini, Jaime D. Mondragón, Esther E. Bron, Geert J. Biessels, Jurgen A.H.R. Claassen, Janne M. Papma, Huub Middelkoop, Rudi A.J.O. Dierckx, Ronald J.H. Borra, Inez H.G.B. Ramakers, Wiesje M. van der Flier, Natasha M. Maurits, Peter P. De Deyn   +12 more
doaj   +1 more source

Cardiovascular co-morbidities, inflammation and cerebral small vessel disease.

Cardiovascular Research, 2021
Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive impairment and affects all levels of the brain's vasculature. Features include diverse structural and functional changes affecting small arteries and capillaries that ...
Lowri E. Evans, Jade L Taylor, Craig J. Smith, Harry A T Pritchard, A. Greenstein, S. Allan   +5 more
semanticscholar   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants

Nature Communications, 2020
Cerebral small vessel disease is a major cause of stroke and dementia, but its genetic basis is incompletely understood. We perform a genetic study of three MRI markers of the disease in UK Biobank imaging data and other sources: white matter ...
E. Persyn, K. Hanscombe, J. Howson, C. Lewis, M. Traylor, H. Markus   +5 more
semanticscholar   +1 more source

Sex Differences in Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis

Frontiers in Neurology, 2021
Background: Cerebral small vessel disease (SVD) is a common cause of stroke, mild cognitive impairment, dementia and physical impairments. Differences in SVD incidence or severity between males and females are unknown.
Lorena Jiménez-Sánchez, Olivia K. L. Hamilton, Ú. Clancy, E. Backhouse, C. R. Stewart, M. Stringer, F. Doubal, J. Wardlaw   +7 more
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Targeting the brain’s glymphatic pathway: A novel therapeutic approach for cerebral small vessel disease

Neural Regeneration Research
Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels, often leading to stroke and dementia.
Yuhui Ma, Yan Han
doaj   +1 more source

Large Vessel Disease Modifies the Relationship Between Kidney Injury and Cerebral Small Vessel Disease

Frontiers in Neurology, 2018
Background: Recent studies have shown that renal disease is associated with magnetic resonance imaging (MRI) markers of cerebral small vessel disease (CSVD), independent of traditional vascular risk factors.
Dong-Hui Ao, Fei-Fei Zhai, Fei Han, Li-Xin Zhou, Jun Ni, Ming Yao, Ding-Ding Zhang, Ming-Li Li, Xiao-Hong Fan, Zheng-Yu Jin, Li-Ying Cui, Shu-Yang Zhang, Yi-Cheng Zhu   +12 more
doaj   +1 more source

The Contribution of Small Vessel Disease to Neurodegeneration: Focus on Alzheimer’s Disease, Parkinson’s Disease and Multiple Sclerosis

International Journal of Molecular Sciences, 2021
Brain small vessel disease (SVD) refers to a variety of structural and functional changes affecting small arteries and micro vessels, and manifesting as white matter changes, microbleeds and lacunar infarcts.
F. Paolini Paoletti, S. Simoni, L. Parnetti, L. Gaetani   +3 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source