Results 51 to 60 of about 406,163 (314)

Distributed machining control and monitoring using smart sensors/actuators [PDF]

, 2004
The study of smart sensors and actuators led, during the past few years, to the development of facilities which improve traditional sensors and actuators in a necessary way to automate production systems. In an other context, many studies are carried out
Desforges, Xavier, Geneste, Laurent, Habbadi, Abdallah, Soler, François   +3 more
core   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Flexible data input layer architecture (FDILA) for quick-response decision making tools in volatile manufacturing systems [PDF]

, 2008
This paper proposes the foundation for a flexible data input management system as a vital part of a generic solution for quick-response decision making.
Komashie, A, Mousavi, A, Tavakoli, S
core   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Microstructure and Mechanical Properties of Magnesium ZRE1 (Mg-Zn-Zr) Alloy with Rare Earth Element (Samarium) Addition

International Journal of Technology
The influences of rare earth (RE) samarium (Sm) added contents to ZRE1 (Mg-Zn-Zr) magnesium (Mg) cast alloy over strength properties to be investigated.
Ikhwan Shah Tisadi Tukiat, Nur Kamilah Yusuf, Haikal Khaireez, Sami Al-Alimi, Mohd Amri Lajis, Shazarel Shamsudin, Nasha Emieza Ruhaizat   +6 more
doaj   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

A Model-Based Approach to Automated Validation and Generation of PLC Code for Manufacturing Equipment in Regulated Environments

Applied Sciences, 2022
Validation is a critical stage of the equipment design process as it provides documentary evidence that the equipment is performing as per specification and ensures consistent product quality is maintained at all times. The advent of Industry 4.0 has led
Damian McCarthy, Dermot McMorrow, Noel P. O’Dowd, Conor T. McCarthy, Eoin P. Hinchy   +4 more
doaj   +1 more source

Energy efficiency in discrete-manufacturing systems: insights, trends, and control strategies [PDF]

, 2019
Since the depletion of fossil energy sources, rising energy prices, and governmental regulation restrictions, the current manufacturing industry is shifting towards more efficient and sustainable systems.
Diaz Castañeda, Jenny Lorena, Ocampo-Martínez, Carlos   +1 more
core   +2 more sources

Bistable Mechanisms 3D Printing for Mechanically Programmable Vibration Control

Advanced Engineering Materials, EarlyView.
This work introduces a 3D‐printed bistable mechanism integrated into tuned mass dampers (TMDs) for mechanically adaptive passive vibration suppression. Through optimized geometry, the bistable design provides adaptable vibration reduction across a broad range of scenarios, achieving effective vibration mitigation without complex controls or external ...
Ali Zolfagharian, Frédéric Demoly, Mohammad Lakhi, Bernard Rolfe, Mahdi Bodaghi   +4 more
wiley   +1 more source

Geometric Optimization and Mechanical Performance Enhancement of Auxetic Structures for High‐Impact Applications Through Fused Deposition Modeling

Advanced Engineering Materials, EarlyView.
This study explores the mechanical performance of three auxetic structures, identifying a re‐entrant‐star hybrid as the most effective for impact absorption. Finite element simulations and experiments demonstrate significant gains in energy absorption and flexural strength after geometric optimization. This study investigates the mechanical performance
Malik Hassan, Manjusri Misra, Alexander Bardelcik, Stefano Gregori, Amar K. Mohanty   +4 more
wiley   +1 more source