Results 41 to 50 of about 6,343,089 (288)

Closed-form solutions for the optimal parameters of three inerter-enhanced dampers (IEDs) equipped on a ground acceleration-excited structure

Urban Lifeline
Replacing the viscous damper of tuned mass damper (TMD) with the proposed inerter-enhanced dampers (IEDs), novel vibration mitigation methods, namely the IED-TMDs, are proposed.
Jiao Li, Xiaolin Qiao, Zhibao Cheng, Zhifei Shi   +3 more
doaj   +1 more source

An Innovative Heating Solution for Sustainable Agriculture: A Feasibility Study on the Integration of Phase Change Materials as Passive Heating Elements

Applied Sciences
In this study, we investigate an innovative option for the ecological management of agricultural land. The focus is on the use of phase change materials (PCMs) for passive temperature regulation in greenhouses and fruit crop fields in order to reduce ...
Stephan M. Thaler, Josef Zwatz, Pascal Nicolay, Robert Hauser, Roman Lackner   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Model‐Based Synchronization of Dielectric Elastomers and Membrane Pumps for Performance‐Optimized, Space‐Efficient, and Application‐Specific Pump Design

Engineering Reports
This work presents a new approach to designing high‐performance and efficient pumps based on dielectric elastomer actuators. By considering the entire system including load from the beginning of the design process, the advantages of dielectric elastomers
M. Baltes, D. Bruch, P. Motzki
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Effect of Piezo-Embedded Inverted Flag in Free Shear Layer Wake

Aerospace, 2019
The use of flexible inverted piezo embedded Polyvinylidene Difluoride (PVDF) as a simultaneous energy harvester and as a wake sensor is explored. The oscillation amplitude (characterized by voltage output) and oscillation frequency of the piezo-embedded ...
Sidaard Gunasekaran, Grant Ross
doaj   +1 more source

Robust porous hydrogen-bonded organic frameworks: Synthesis and applications in gas adsorption and separation

Giant, 2023
Being an emerging family of crystalline porous materials, hydrogen-bonded organic frameworks (HOFs) are types of ordered supramolecular structures that constructed from organic linkers (including those with organometallic units) via mainly hydrogen bonds.
Xiao-Juan Xi, Yang Li, Fei-Fan Lang, Lin Xu, Jiandong Pang, Xian-He Bu   +5 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Research Progress and Application Perspectives of 4D Printing

Journal of Aeronautical Materials, 2018
4D printing technology has attracted people's attention since it came up in 2013. 4D printing is a kind of new manufacturing technology which is based on 3D printing and smart materials. In other word, 4D printing is evolved from 3D printing and aimed at
WANG Ya'nan, WANG Fanghui, WANG Zhongming, LIU Jianjun, ZHU Hong   +4 more
doaj   +1 more source