Results 41 to 50 of about 195,059 (258)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Snap evaporation of droplets on smooth topographies

Nature Communications, 2018
Droplet evaporation control has applications in inkjet printing and surface patterning. Here, the authors show that on slippery curved substrates droplets evaporate by slowly retracting and then suddenly snapping, which can be exploited to design ...
Gary G. Wells, Élfego Ruiz-Gutiérrez, Youen Le Lirzin, Anthony Nourry, Bethany V. Orme, Marc Pradas, Rodrigo Ledesma-Aguilar   +6 more
doaj   +1 more source

Morphology simulation of drop-on-demand inkjet-printed droplets

npj Flexible Electronics, 2022
Inkjet-printed electronics have become a popular research topic in recent years. For common drop-on-demand (DOD) inkjet printing technology, uneven edges are a universal problem.
Shaowei Hu, Wenbo Zhu, Wanchun Yang, Mingyu Li   +3 more
doaj   +1 more source

Metformin Hydrochloride Significantly Inhibits Rotavirus Infection in Caco2 Cell Line, Intestinal Organoids, and Mice

Pharmaceuticals, 2023
Rotavirus is one of the main pathogens that causes severe diarrhea in children under the age of 5, primarily infecting the enterocytes of the small intestine.
Rui Zhang, Cui Feng, Dandan Luo, Ruibo Zhao, Perumal Ramesh Kannan, Yuebang Yin, Muhammad Zubair Iqbal, Yeting Hu, Xiangdong Kong   +8 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Fuel Reactivity Controlled Autoignition and Combustion Characteristics in a Supersonic Combustor With Different Turbulence Models

International Journal of Aerospace Engineering
The choice of turbulence model significantly impacts the prediction of the supersonic combustion flow field. In this study, the transient autoignition process and steady supersonic combustion performance of methane fuel with adjustable reactivity in a ...
Zihan Wang, Qi Luo, Yifan Lv, Zuming Liu, Ziang Han, Xiaojie Li   +5 more
doaj   +1 more source

Polymeric Hydrogels—A Promising Platform in Enhancing Water Security for a Sustainable Future

Advanced Materials Interfaces, 2021
Although water is essential for global health and the socio‐economic development of modern society, providing fresh water universally in a sustainable and affordable manner, for both developing and industrialized communities, is challenging.
Siew‐Leng Loo, Lía Vásquez, Athanassia Athanassiou, Despina Fragouli   +3 more
doaj   +1 more source

Droplet-Based Microfluidic Preparation of Shape-Variable Alginate Hydrogel Magnetic Micromotors

Nanomaterials, 2021
This article introduces a facile droplet-based microfluidic method for the preparation of Fe3O4-incorporated alginate hydrogel magnetic micromotors with variable shapes.
Cheng Zhang, Yong Wang, Yuduo Chen, Xing Ma, Wenjun Chen   +4 more
doaj   +1 more source